Ordered nanostructured amphiphile self-assembly materials from endogenous nonionic unsaturated monoethanolamide lipids in water

Langmuir : the ACS Journal of Surfaces and Colloids
Sharon M SagnellaCalum J Drummond

Abstract

The self-assembly, solid state and lyotropic liquid crystalline phase behavior of a series of endogenous n-acylethanolamides (NAEs) with differing degrees of unsaturation, viz., oleoyl monoethanolamide, linoleoyl monoethanolamide, and linolenoyl monoethanolamide, have been examined. The studied molecules are known to possess inherent biological function. Both the monoethanolamide headgroup and the unsaturated hydrophobe are found to be important in dictating the self-assembly behavior of these molecules. In addition, all three molecules form lyotropic liquid crystalline phases in water, including the inverse bicontinuous cubic diamond (Q(II)(D)) and gyroid (Q(II)(G)) phases. The ability of the NAE's to form inverse cubic phases and to be dispersed into ordered nanostructured colloidal particles, cubosomes, in excess water, combined with their endogenous nature and natural medicinal properties, makes this new class of soft mesoporous amphiphile self-assembly materials suitable candidates for investigation in a variety of advanced multifunctional applications, including encapsulation and controlled release of therapeutic agents and incorporation of medical imaging agents.

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Citations

Dec 15, 2012·Journal of Colloid and Interface Science·Xavier MuletCalum J Drummond
Jun 29, 2010·International Journal of Pharmaceutics·Xavier MuletCalum J Drummond
Mar 29, 2014·Chemistry : a European Journal·George C FeastG Paul Savage
May 16, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Sharon M SagnellaMaria Kavallaris
Aug 16, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Mohammad YounusShakila B Rizwan
Mar 30, 2017·International Journal of Molecular Sciences·Raffaele ContePierfrancesco Cerruti
Jul 18, 2019·Soft Matter·Vijai Shankar BalachandranGeorge John
Jun 17, 2020·ChemPlusChem·Jerikho C BulanadiMinoo J Moghaddam
Apr 10, 2019·Nature Nanotechnology·Livia Salvati ManniRaffaele Mezzenga
Mar 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Abhishek GuptaMinoo J Moghaddam
Nov 10, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Xavier MuletCalum J Drummond

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