PMID: 3746912May 20, 1986Paper

Ordering of the myofilament lattice in muscle fibers

Journal of Molecular Biology
T Matsuda, R J Podolsky

Abstract

The effect of pH on the muscle filament lattice in skinned rabbit psoas fibers was studied by X-ray diffraction. In relaxed fibers, the intensity of the 11 equatorial reflection, I11, remained constant between pH 7.0 and pH 6.0 and fell markedly when the pH was decreased to 5.5. The intensity of the 10 reflection was almost constant over this pH range. These results indicate that the thick-filament lattice is more stable than that of the thin filaments, and that the thin filaments are positioned within the thick-filament lattice by a charge-dependent force. In rigor fibers, the decrease in I11 over this pH range was much smaller, which shows that the thin filament lattice can also be stabilized by the presence of actomyosin crossbridges. These conclusions were confirmed by electron microscopy. Thus, the thin filaments can be positioned in the trigonal positions of the thick-filament lattice by two different mechanisms, one electrostatic and the other steric.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·K WangA Tu
Jul 1, 1985·Biophysical Journal·G R NaylorG F Elliott
Feb 12, 1971·Nature·A Miller, J Woodhead-Galloway
Apr 1, 1973·Biophysical Journal·S L Brenner, D A McQuarrie
Oct 1, 1968·Journal of Theoretical Biology·G F Elliott
Oct 1, 1984·The Journal of Cell Biology·K MaruyamaY Umazume
Dec 5, 1984·Journal of Molecular Biology·J TrinickA Whiting
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T Matsuda, R J Podolsky
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B BrennerE Eisenberg
Oct 1, 1980·Biophysical Journal·B M Millman, B G Nickel

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Citations

Feb 2, 2006·Journal of Vascular Research·Ichiro WakabayashiKlaus Groschner
Apr 30, 1998·Physiological Reviews·B M Millman
Feb 28, 2021·Annual Review of Biophysics·Joseph D PowersThomas L Daniel

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