OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2 -INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES

Depression and Anxiety
Philip L JohnsonAnantha Shekhar

Abstract

The neuropeptides orexin A and B play a role in reward and feeding and are critical for arousal. However, it was not initially appreciated that most prepro-orexin synthesizing neurons are almost exclusively concentrated in the perifornical hypothalamus, which when stimulated elicits panic-associated behavior and cardiovascular responses in rodents and self-reported "panic attacks" and "fear of dying" in humans. More recent studies support a role for the orexin system in coordinating an integrative stress response. For instance, orexin neurons are highly reactive to anxiogenic stimuli, are hyperactive in anxiety pathology, and have strong projections to anxiety and panic-associated circuitry. Although the two cognate orexin receptors are colocalized in many brain regions, the orexin 2 receptor (OX2R) most robustly maps to the histaminergic wake-promoting region, while the orexin 1 receptor (OX1R) distribution is more exclusive and dense in anxiety and panic circuitry regions, such as the locus ceruleus. Overall, this suggests that OX1Rs play a critical role in mobilizing anxiety and panic responses. Here, we used a CO2 -panic provocation model to screen a dual OX1/2R antagonist (DORA-12) to globally inhibit orexin activity, then...Continue Reading

References

Oct 1, 1989·Journal of the Autonomic Nervous System·Y FukudaA Trzebski
Aug 1, 1986·The Journal of Nervous and Mental Disease·G E Tesar, J F Rosenbaum
Dec 21, 1967·The New England Journal of Medicine·F N Pitts, J N McClure
Feb 1, 1995·Pharmacology, Biochemistry, and Behavior·A Shekhar, J S Katner
Apr 1, 1994·The American Journal of Psychiatry·J M GormanD F Klein
Dec 1, 1995·Pharmacology, Biochemistry, and Behavior·S K Sanders, A Shekhar
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·L de LeceaJ G Sutcliffe
Nov 20, 1998·FEBS Letters·P TrivediX M Guan
Mar 30, 2000·The American Journal of Psychiatry·J M GormanJ D Coplan
Apr 20, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·J MassanaA Otero
May 23, 2001·The Journal of Comparative Neurology·J N MarcusJ K Elmquist
Nov 5, 2003·Frontiers in Neuroendocrinology·Alastair V Ferguson, Willis K Samson
Jun 29, 2005·Journal of Psychopharmacology·Philip L JohnsonChristopher A Lowry
May 11, 2007·Brain : a Journal of Neurology·Thomas C ThannickalJerome M Siegel
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rhîannan H WilliamsDenis Burdakov
Apr 14, 2009·The Journal of Pharmacology and Experimental Therapeutics·Christine DugovicTimothy W Lovenberg
May 16, 2009·Respiratory Physiology & Neurobiology·Jinko SunanagaTomoyuki Kuwaki
Oct 27, 2009·Journal of Neurosurgery·W Bryan WilentDonald M Whiting
Dec 29, 2009·Nature Medicine·Philip L JohnsonAnantha Shekhar
Jan 16, 2010·Journal of Applied Physiology·H V Forster, C A Smith
Jan 16, 2010·Journal of Applied Physiology·Patrice G GuyenetRoy Kanbar
Jan 19, 2010·Journal of Psychopharmacology·Philip L JohnsonChristopher A Lowry
Mar 29, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philip L JohnsonAnantha Shekhar
May 5, 2012·Physiology & Behavior·Philip L JohnsonAnantha Shekhar
Jun 14, 2012·Journal of Neural Transmission·Thomas DreslerKatharina Domschke
Jul 21, 2012·Progress in Brain Research·Philip L JohnsonAnantha Shekhar
Jul 21, 2012·Progress in Brain Research·Anthony L GotterJohn J Renger
Oct 31, 2012·Journal of Affective Disorders·Massimiliano GrassiGiampaolo Perna

❮ Previous
Next ❯

Citations

Feb 20, 2016·Expert Opinion on Drug Discovery·Kurt L Hoffman
Apr 6, 2017·EBioMedicine·Jing LuDick F Swaab
Aug 31, 2016·Behavioural Brain Research·Huiying WangGilbert J Kirouac
Aug 1, 2018·Expert Opinion on Pharmacotherapy·Daniela CaldirolaGiampaolo Perna
Oct 26, 2016·Menopause : the Journal of the North American Menopause Society·Lauren M FedericiPhilip L Johnson
Jul 9, 2017·Cell and Tissue Research·Eduardo E Benarroch
Jan 19, 2019·Alternatives to Laboratory Animals : ATLA·Kathrin Herrmann, Paul Flecknell
May 24, 2017·Frontiers in Behavioral Neuroscience·Sujin YunChristine Dugovic
Jul 28, 2020·Translational Psychiatry·Lucía Améndola, Daniel M Weary
Nov 20, 2016·Annual Review of Pharmacology and Toxicology·Paul J ColemanJohn J Renger
Dec 14, 2019·Scientific Reports·Lucía AméndolaDaniel M Weary
Jan 23, 2021·PloS One·Lucía AméndolaDaniel M Weary
Nov 8, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Priska KaufmannJasper Dingemanse
Apr 24, 2021·Journal of Experimental Pharmacology·Daniela CaldirolaGiampaolo Perna
Jun 9, 2021·Journal of Medicinal Chemistry·Dehui ZhangYanan Zhang
Dec 1, 2020·Journal of Psychiatric Research·Umit Tural, Dan V Iosifescu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.

Related Papers

The Journal of Pharmacology and Experimental Therapeutics
Pascal BonaventureChristine Dugovic
Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih
Yu-yan ZhaoGuo-liang Liu
The Journal of Comparative Neurology
J N MarcusJ K Elmquist
© 2021 Meta ULC. All rights reserved