Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network.

Physiology & Behavior
Philip L JohnsonAnantha Shekhar

Abstract

Although the hypothalamic orexin system is known to regulate appetitive behaviors and promote wakefulness and arousal (Sakurai, 2007 [56]), this system may also be important in adaptive and pathological anxiety/stress responses (Suzuki et al., 2005 [4]). In a recent study, we demonstrated that CSF orexin levels were significantly higher in patients experiencing panic attacks compared to non-panicking depressed subjects (Johnson et al., 2010 [9]). Furthermore, genetically silencing orexin synthesis or blocking orexin 1 receptors attenuated lactate-induced panic in an animal model of panic disorder. Therefore, in the present study, we tested if orexin (ORX) modulates panic responses and brain pathways activated by two different panicogenic drugs. We conducted a series of pharmacological, behavioral, physiological and immunohistochemical experiments to study the modulation by the orexinergic inputs of anxiety behaviors, autonomic responses, and activation of brain pathways elicited by systemic injections of anxiogenic/panicogenic drugs in rats. We show that systemic injections of two different anxiogenic/panicogenic drugs (FG-7142, an inverse agonist at the benzodiazepine site of the GABA(A) receptor, and caffeine, a nonselective ...Continue Reading

References

Oct 1, 1996·Pharmacology, Biochemistry, and Behavior·A ShekharW J McBride
Jan 1, 1997·Depression and Anxiety·A S LinU D McCann
Jan 7, 1998·Neuroscience and Biobehavioral Reviews·F G GraeffP O Mora
Jan 7, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M DavisY Lee
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·L de LeceaJ G Sutcliffe
Jul 23, 1999·Annals of the New York Academy of Sciences·M D CassellC Shi
May 23, 2001·The Journal of Comparative Neurology·J N MarcusJ K Elmquist
Feb 7, 2002·Regulatory Peptides·Tetsuro ShirasakaHiroshi Kannan
May 17, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yuji KayabaTomoyuki Kuwaki
Dec 4, 2003·The Journal of Comparative Neurology·Hong-Wei Dong, Larry W Swanson
Apr 10, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B C SamuelsJ A DiMicco
Jun 18, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ned H KalinRichard J Davidson
Aug 15, 2006·Trends in Neurosciences·Glenda C Harris, Gary Aston-Jones
Feb 15, 2007·Nature Reviews. Neuroscience·Takeshi Sakurai
Dec 29, 2009·Nature Medicine·Philip L JohnsonAnantha Shekhar
Mar 29, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philip L JohnsonAnantha Shekhar

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Citations

Dec 24, 2013·Current Psychiatry Reports·Fabio PizzaGiuseppe Plazzi
Aug 19, 2014·Neuroscience and Biobehavioral Reviews·Philip L JohnsonAnantha Shekhar
Oct 11, 2014·Nature Reviews. Neuroscience·Takeshi Sakurai
Aug 21, 2013·Brain Structure & Function·Xiaoyu ChenGilbert J Kirouac
Jul 23, 2014·Current Opinion in Neurobiology·William J Giardino, Luis de Lecea
Dec 30, 2014·Expert Opinion on Investigational Drugs·Giampaolo PernaDaniela Caldirola
Jan 7, 2016·Current Psychiatry Reports·Shi-Bin LiLuis de Lecea
Sep 4, 2015·Depression and Anxiety·Philip L JohnsonAnantha Shekhar
Mar 20, 2014·British Journal of Pharmacology·Corey BaimelStephanie L Borgland
Jul 22, 2014·Medicinal Research Reviews·Quanhui ChenDong Gao
Apr 9, 2014·Neuroscience and Biobehavioral Reviews·Newton S Canteras, Frederico G Graeff
Dec 5, 2014·Psychopharmacology·Christiane A Pané-FarréAlfons O Hamm
Jul 11, 2016·Neuropharmacology·Hanna E KastmanAndrew J Lawrence
Aug 2, 2016·Neuroscience and Biobehavioral Reviews·Pascal Carrive
Sep 7, 2016·Autonomic Neuroscience : Basic & Clinical·Eric J MartinLinda F Hayward
Aug 31, 2016·Behavioural Brain Research·Huiying WangGilbert J Kirouac
Jun 6, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alessandro GozziAngelo Bifone
Dec 17, 2019·Alcoholism, Clinical and Experimental Research·Jung S Kim, Rémi Martin-Fardon
Feb 19, 2020·British Journal of Clinical Pharmacology·Priska KaufmannJasper Dingemanse
Jan 15, 2015·The Journal of Pharmacology and Experimental Therapeutics·Pascal BonaventureChristine Dugovic
Sep 25, 2020·Translational Psychiatry·Katherine E OdegaardGurudutt Pendyala
Jan 10, 2018·Frontiers in Physiology·Phuong H NguyenSami Dridi
May 27, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charly BrouillardCaroline Sévoz-Couche
Jan 12, 2021·Frontiers in Psychiatry·Amir GarakaniDan V Iosifescu
Nov 8, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Priska KaufmannJasper Dingemanse
Apr 24, 2021·Journal of Experimental Pharmacology·Daniela CaldirolaGiampaolo Perna
Jun 15, 2021·Neuroscience·Victor P M N SoaresRafael C Almada
Aug 21, 2021·Peptides·Daria Peleg-Raibstein, Denis Burdakov

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