Orexin A depolarises rat intergeniculate leaflet neurons through non-selective cation channels

The European Journal of Neuroscience
Katarzyna Palus-ChramiecM H Lewandowski

Abstract

Orexins/hypocretins are hypothalamic neuropeptides that have a variety of functions, including maintenance of arousal, control over the sleep/wake cycle, reward and feeding. Accumulating evidence links orexins to the time-keeping system with a documented action in the master clock-the suprachiasmatic nucleus. The intergeniculate leaflet (IGL) is a thalamic structure with the well-known function of collecting photic and non-photic cues to adjust the rhythm of the suprachiasmatic nucleus to changing environmental conditions. The IGL consists of GABAergic neurons that are intrinsically active, even in slice preparations. Our previous studies revealed the excitatory postsynaptic effects of orexins on single IGL neurons, even though the ionic mechanism underlying this effect remained elusive. Therefore, in this study, we used patch clamp electrophysiology to identify the ions and distinct ion channels responsible for the observed depolarisations. The major finding of this article is that the orexin A-evoked depolarisation of IGL neurons depends on non-selective cation channels, implicating the orexinergic tone in establishing the basal firing rate in these cells. The data presented here strengthen the mutual connections between the ...Continue Reading

References

May 1, 1985·The Journal of Physiology·R H Kramer, R S Zucker
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·L de LeceaJ G Sutcliffe
May 13, 1999·Brain Research·T NambuK Goto
Feb 16, 2000·Neuroreport·M H LewandowskiA Wołkowska
Jul 6, 2000·The Journal of Biological Chemistry·P E LundK E Akerman
Feb 13, 2001·Trends in Pharmacological Sciences·P TsaoM von Zastrow
Jan 16, 2003·Behavioural Brain Research·Tomasz Błasiak, Marian H Lewandowski
Apr 19, 2003·Journal of Neurophysiology·Q V HoangY Nakajima
Jun 30, 2004·Brain Research·Anna Blasiak, Marian H Lewandowski
Nov 13, 2004·The Journal of Biological Chemistry·Kim P LarssonKarl E O Akerman
Dec 13, 2006·The European Journal of Neuroscience·T BlasiakM H Lewandowski
Sep 18, 2007·Brain Research·Panchanan MaitiG Ilavazhagan
Aug 5, 2008·Mini Reviews in Medicinal Chemistry·Fernando Peña, Benito Ordaz
Oct 24, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zayd M Khaliq, Bruce P Bean
Apr 10, 2010·The European Journal of Neuroscience·J David GlassJessie M Francl
Dec 24, 2010·PloS One·Vesna Cvetkovic-LopesMichel Mühlethaler
Feb 23, 2011·Neuron·Jun ZhangJian-Jun Wang
Feb 26, 2011·Journal of Pharmacology & Pharmacotherapeutics·Carol KilkennyDouglas G Altman
Oct 5, 2012·American Journal of Physiology. Cell Physiology·Jyrki P Kukkonen
Oct 9, 2012·Neuron·Anthony N van den Pol
Jul 16, 2013·British Journal of Pharmacology·C S Leonard, J P Kukkonen
Oct 10, 2013·British Journal of Pharmacology·Jingcheng LiLuis de Lecea
Mar 7, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mino D C BelleHugh D Piggins
Sep 30, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masaru IshibashiChristopher S Leonard
Mar 27, 2018·The Journal of Physiology·Lukasz ChrobokMarian Henryk Lewandowski

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Citations

Oct 1, 2020·The Journal of Physiology·Lukasz ChrobokMarian Henryk Lewandowski
Sep 18, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lukasz ChrobokMarian Henryk Lewandowski

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