Orexin A-mediated AKT signaling in the dentate gyrus contributes to the acquisition, expression and reinstatement of morphine-induced conditioned place preference

Addiction Biology
Sui-Jun GuoWen-Jun Xin

Abstract

Accumulating evidence indicates that the hippocampal dentate gyrus (DG), a critical brain region contributing to learning and memory, is involved in the addiction and relapse to abused drugs. Emerging studies also suggest the role of orexin signaling in the rewarding behavior induced by repeated exposure to opiates. In the present study, we investigated the dynamic adaptation of orexin signaling in the DG and its functional significance in the acquisition, expression, maintenance of and relapse to rewarding behavior induced by morphine. Repeated place conditioning with morphine significantly increased the orexin A content released from the lateral hypothalamic area projecting neurons into the DG. Local infusions of orexin A into the DG sensitized the acquisition of and relapse to the conditioned place preference induced by morphine. The application of the orexin receptor type 1 (OXR1) antagonist SB334867 significantly abolished the acquisition, expression and maintenance of the conditioned place preference induced by repeated exposure to morphine. Furthermore, the significant increase of the phosphorylation of AKT in the DG was associated with preference for the morphine-paired chamber in rats, which was reversed by the local a...Continue Reading

References

Apr 1, 1993·Hippocampus·M W Jung, B L McNaughton
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·L de LeceaJ G Sutcliffe
May 13, 1999·Brain Research·T NambuK Goto
Apr 3, 2001·Annual Review of Neuroscience·J T WillieM Yanagisawa
Oct 2, 2002·Journal of Neurochemistry·Irving M RetiJay M Baraban
Sep 17, 2003·The Journal of Comparative Neurology·Diane L RosinPatrice G Guyenet
Mar 15, 2005·Psychopharmacology·Bernard Le Foll, Steven R Goldberg
Aug 16, 2005·Nature·Glenda C HarrisGary Aston-Jones
Jan 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minoru NaritaTsutomu Suzuki
Aug 10, 2006·Hippocampus·David M Smith, Sheri J Y Mizumori
Jul 23, 2008·Neurobiology of Learning and Memory·V Hernández-RabazaJ J Canales
Nov 1, 2008·The European Journal of Neuroscience·Nicole M VittozCraig W Berridge
Oct 10, 2009·Brain Research·Gary Aston-JonesKimberlei A Richardson
Dec 2, 2009·Frontiers in Behavioral Neuroscience·Ulises M Ricoy, Joe L Martinez
Aug 24, 2010·Behavioural Brain Research·Esmaeil AkbariElham Ghanbarian
Nov 16, 2010·Behavioural Brain Research·Ennio AvolioMarcello Canonaco
Dec 30, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Patrick RecintoChitra D Mandyam
Mar 17, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kimberlei A Richardson, Gary Aston-Jones
Jul 21, 2012·Progress in Brain Research·Philip L JohnsonAnantha Shekhar
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xu-Hong WeiXian-Guo Liu
Mar 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Liya YangXinmin Simon Xie
Jun 22, 2013·Behavioural Pharmacology·Esmail RiahiAbbas Haghparast
Nov 19, 2013·Journal of Molecular Neuroscience : MN·Paulina SokołowskaJolanta B Zawilska

❮ Previous
Next ❯

Citations

Jul 4, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anna BerounKasia Radwanska
Nov 3, 2020·Frontiers in Behavioral Neuroscience·Greer McKendrick, Nicholas M Graziane
Nov 27, 2018·Brain Research·Shahram ZarrabianAbbas Haghparast

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.