Orexin in Rostral Hotspot of Nucleus Accumbens Enhances Sucrose 'Liking' and Intake but Scopolamine in Caudal Shell Shifts 'Liking' Toward 'Disgust' and 'Fear'

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Daniel C CastroK C Berridge

Abstract

The nucleus accumbens (NAc) contains a hedonic hotspot in the rostral half of medial shell, where opioid agonist microinjections are known to enhance positive hedonic orofacial reactions to the taste of sucrose ('liking' reactions). Within NAc shell, orexin/hypocretin also has been reported to stimulate food intake and is implicated in reward, whereas blockade of muscarinic acetylcholine receptors by scopolamine suppresses intake and may have anti-reward effects. Here, we show that NAc microinjection of orexin-A in medial shell amplifies the hedonic impact of sucrose taste, but only within the same anatomically rostral site, identical to the opioid hotspot. By comparison, at all sites throughout medial shell, orexin microinjections stimulated 'wanting' to eat, as reflected by increases in intake of palatable sweet chocolates. At NAc shell sites outside the hotspot, orexin selectively enhanced 'wanting' to eat without enhancing sweetness 'liking' reactions. In contrast, microinjections of the antagonist scopolamine at all sites in NAc shell suppressed sucrose 'liking' reactions as well as suppressing intake of palatable food. Conversely, scopolamine increased aversive 'disgust' reactions elicited by bitter quinine at all NAc she...Continue Reading

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Citations

Jul 26, 2018·The European Journal of Neuroscience·Gabrielle D GibsonGavan P McNally
Nov 27, 2018·Physiological Reviews·Lindsey A Schier, Alan C Spector
Oct 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Daniel C Castro, Kent C Berridge
Oct 12, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yi ZhangJohn A Rogers
Feb 6, 2019·Nature Reviews. Neuroscience·Kent C Berridge
Jun 3, 2017·Frontiers in Endocrinology·Ryan Michael Cassidy, Qingchun Tong
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Feb 21, 2021·Neuroscience and Biobehavioral Reviews·Gavan P McNally
Jun 20, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jacqueline B MehrMorgan H James
Jul 10, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shani GendelisYonatan M Kupchik
Oct 13, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caroline B PantazisGary Aston-Jones
Oct 15, 2021·Nature·Daniel C CastroMichael R Bruchas

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The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
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Stephen V MahlerK C Berridge
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