PMID: 16645455Apr 29, 2006Paper

Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia

Anesthesiology
Hailong DongTakashi Higuchi

Abstract

Cholinergic arousal system plays an important role in the maintenance of consciousness. The authors investigated whether the intrabasalis injection of orexin-A or orexin-B and the electrically stimulated pedunculopontine tegmentum nuclei (PPTg: the origin of cholinergic ascending pathways) may alter acetylcholine efflux and electroencephalographic activity in the somatosensory cortex in relation to the orexinergic system in isoflurane-anesthetized rats. Either orexin-A (10, 30, or 100 pmol) or orexin-B (10, 30, or 100 pmol) (n = 6 each) was injected into the basal forebrain while the electroencephalogram was measured during 1.0 minimum alveolar concentration (1.2%) isoflurane anesthesia. Injection of Ringer's solution was used as a control. The PPTg was electrically stimulated twice with the following conditions: 1-s stimulus train (0.2 ms, 100 Hz, 400 microA) per min for 20 min. Twenty minutes before the second PPTg stimulation, Ringer's solution or 20 microg SB334867, an orexin-1 receptor antagonist (n = 5 each) was injected into the basal forebrain. Injection of orexin-A (30 and 100 pmol) and orexin-B (100 pmol) significantly increased the acetylcholine efflux in the somatosensory cortex (P < 0.05). Injection of orexin-A (10...Continue Reading

References

Nov 20, 1998·FEBS Letters·P TrivediX M Guan
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·J J HaganN Upton
Mar 11, 2000·The European Journal of Neuroscience·D C PiperA J Hunter
Jul 25, 2000·Trends in Neurosciences·T S Kilduff, C Peyron
Mar 17, 2001·British Journal of Pharmacology·D SmartJ C Jerman
Nov 24, 2001·Trends in Neurosciences·C B SaperT E Scammell
Apr 12, 2003·Pflügers Archiv : European journal of physiology·E Lucas-MeunierM Amar
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Barbara E Jones
Oct 29, 2003·Neuroscience·T KushikataA Matsuki
Mar 5, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·David A FishbainR Steele Rosomoff
Jan 25, 2005·Neuroscience·J FadelL R Reznikov
Feb 1, 2005·Brain Research·Claude M Schofield, Neil L Harrison
Oct 28, 2005·Nature·Clifford B SaperJun Lu
Nov 25, 2005·Anesthesiology·Ralph Lydic, Helen A Baghdoyan

❮ Previous
Next ❯

Citations

Feb 29, 2016·Pharmacological Reports : PR·Anil KumarSupriti Choudhary
Nov 20, 2012·Sleep Medicine Clinics·Christopher J WatsonRalph Lydic
Aug 21, 2012·Anesthesiology Clinics·George A Mashour, Dinesh Pal
Sep 20, 2011·Neuropharmacology·Xiaojun JiaZhian Hu
Feb 1, 2011·Sleep Medicine Clinics·Christopher J WatsonRalph Lydic
Feb 5, 2008·Critical Care Clinics·Robert E HoeschRomergryko G Geocadin
Feb 19, 2008·Pharmacology, Biochemistry, and Behavior·Jim Fadel, Danielle Frederick-Duus
Sep 3, 2009·Acta Physiologica·E ArrigoniT E Scammell
Dec 30, 2008·Brain Research·Matthew A KoenigRomergryko G Geocadin
Aug 31, 2014·Progress in Neurobiology·L Stan LeungIan Herrick
Jul 10, 2012·Peptides·Haydar Ali ErkenSebahat Turgut
Aug 24, 2013·Anesthesiology·Siew Kian TaiL Stan Leung
Dec 16, 2016·Scientific Reports·Tomokazu TsurugizawaFusao Kato
Mar 19, 2019·Anesthesia and Analgesia·Max B KelzKen Solt
Mar 7, 2020·Neuropharmacology·Shi-Bin Li, Luis de Lecea
May 12, 2021·CNS Neuroscience & Therapeutics·Ao LiHaopeng Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.