Organ- and species-specific biological activity of rosmarinic acid

Toxicology in Vitro : an International Journal Published in Association with BIBRA
R IswandanaPeter Olinga

Abstract

Rosmarinic acid (RA), a compound found in several plant species, has beneficial properties, including anti-inflammatory and antibacterial effects. We investigated the toxicity, anti-inflammatory, and antifibrotic effects of RA using precision-cut liver slices (PCLS) and precision-cut intestinal slices (PCIS) prepared from human, mouse, and rat tissue. PCLS and PCIS were cultured up to 48 h in the absence or presence of RA. Gene expression of the inflammatory markers: IL-6, IL-8/CXCL1/KC, and IL-1β, as well as the fibrosis markers: pro-collagen 1a1, heat shock protein 47, α-smooth muscle actin, fibronectin (Fn2) and plasminogen activator inhibitor-1 (PAI-1) were evaluated by qPCR. RA was only toxic in murine PCIS. RA failed to mitigate the inflammatory response in most models, while it clearly reduced IL-6 and CXCL1/KC gene expression in murine PCIS at non-toxic concentrations. With regard to fibrosis, RA decreased the gene levels of Fn2 and PAI-1 in murine PCLS, and Fn2 in murine PCIS. Yet, no effect was observed on the gene expression of fibrosis markers in human and rat PCIS. In conclusion, we observed clear organ- and species-specific effects of RA. RA had little influence on inflammation. However, our study further establis...Continue Reading

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Citations

May 29, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Inge M WestraPeter Olinga
Jul 5, 2016·European Journal of Pharmacology·Elisabeth G D StribosHenricus A M Mutsaers
Sep 13, 2017·The AAPS Journal·Mitchel J R RuigrokWouter L J Hinrichs
Jul 12, 2017·British Journal of Pharmacology·Theerut LuangmonkongPeter Olinga
Aug 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xuan CaiYonghong Lu
Aug 31, 2019·Oxidative Medicine and Cellular Longevity·Igor KumburovicGvozden Rosic
Jan 17, 2020·Inflammatory Bowel Diseases·Raditya IswandanaPeter Olinga
Aug 24, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Carin BielPeter Olinga
Mar 20, 2020·Current Pharmaceutical Biotechnology·Sarah AlbogamiAfnan Alattas
Feb 20, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Taiwo O Elufioye, Solomon Habtemariam

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