Abstract
The anti-apoptotic protein Bcl-2, which also has cytoprotective and antioxidant functions might be one of the crucial factors that altogether, establish how a cell may deal with stress and damage, contributing to longevity. Among the controversial issues to understand Bcl-2 functions in vivo, is to establish its content and variation in tissues during an organismal lifespan. In this work we analyzed the changes of Bcl-2 levels in lung, liver, heart, kidney, spleen and brain homogenates obtained from CD1 mice throughout their lifespan (newborn to 24 months). A tendency of increment was observed in all the organs analyzed, except brain where Bcl-2 was not detected. Bcl-2 over-expression during aging could be interpreted as a protective mechanism preventing cell death, despite the overall accumulated cell damage.
References
Aug 1, 1972·British Journal of Cancer·J F KerrA R Currie
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Jan 1, 1995·Neuropeptides·E PeuranenP T Männistö
May 31, 1996·The Journal of Biological Chemistry·C Borner
May 1, 1996·Nature Genetics·G M MartinT E Johnson
Feb 1, 1997·Journal of Neuropathology and Experimental Neurology·A T YachnisT A Eskin
Jun 12, 1999·Neuroscience·S HamnérD Lindholm
Jun 10, 2000·Molecular and Cellular Biology·G VairoJ M Adams
Nov 23, 2000·Nature·T B Kirkwood, S N Austad
Feb 13, 2001·Mechanisms of Ageing and Development·D MontiC Franceschi
Feb 28, 2001·FEBS Letters·M A Pahlavani, D A Vargas
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sharon Phaneuf, Christiaan Leeuwenburgh
Oct 9, 2003·The EMBO Journal·Yelena M JanumyanElizabeth Yang
Oct 14, 2003·Biochemical Pharmacology·Jung-Hee Jang, Young-Joon Surh
Nov 25, 2003·Oncogene·Suzanne CoryJerry M Adams
Mar 5, 2004·Biochimica Et Biophysica Acta·Rizwan S AkhtarKevin A Roth
Sep 8, 2004·Cell Biology International·Mina KönigsbergAlejandro Zentella
Mar 1, 2005·Cell·Judith Campisi
Jun 1, 2005·Biochemical and Biophysical Research Communications·Ryungsa Kim
Aug 2, 2005·Nature Reviews. Cancer·Lodovico Balducci, William B Ershler
Sep 13, 2005·Mechanisms of Ageing and Development·Christopher K PatilJudith Campisi
Citations
May 8, 2008·Biogerontology·Juan C Conde-PérezprinaMina Königsberg
Aug 27, 2009·Biogerontology·Young-Hee LeeHo-Keun Yi
Jul 6, 2013·Progress in Neurobiology·Antero SalminenMikko Hiltunen
Mar 5, 2014·Systems and Synthetic Biology·Subhadip Raychaudhuri, Somkanya C Raychaudhuri
Dec 12, 2012·Ageing Research Reviews·Antero SalminenAnu Kauppinen
Oct 29, 2008·Mutation Research·Jorge Limón-Pacheco, María E Gonsebatt
Dec 4, 2012·Biochemical and Biophysical Research Communications·Longyun PengXiuren Gao
Jan 1, 2013·Cells·Subhadip Raychaudhuri, Somkanya C Raychaudhuri
Feb 6, 2017·Aging·Yubisay Mejías-PeñaMaría J Cuevas