Organ- and tissue-specific alterations in the anti-apoptotic protein Bcl-2 in CD1 female mice of different ages

Biogerontology
Hugo López-AraizaMina Königsberg

Abstract

The anti-apoptotic protein Bcl-2, which also has cytoprotective and antioxidant functions might be one of the crucial factors that altogether, establish how a cell may deal with stress and damage, contributing to longevity. Among the controversial issues to understand Bcl-2 functions in vivo, is to establish its content and variation in tissues during an organismal lifespan. In this work we analyzed the changes of Bcl-2 levels in lung, liver, heart, kidney, spleen and brain homogenates obtained from CD1 mice throughout their lifespan (newborn to 24 months). A tendency of increment was observed in all the organs analyzed, except brain where Bcl-2 was not detected. Bcl-2 over-expression during aging could be interpreted as a protective mechanism preventing cell death, despite the overall accumulated cell damage.

References

Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
May 31, 1996·The Journal of Biological Chemistry·C Borner
Nov 23, 2000·Nature·T B Kirkwood, S N Austad
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sharon Phaneuf, Christiaan Leeuwenburgh
Oct 9, 2003·The EMBO Journal·Yelena M JanumyanElizabeth Yang
Oct 14, 2003·Biochemical Pharmacology·Jung-Hee Jang, Young-Joon Surh
Nov 25, 2003·Oncogene·Suzanne CoryJerry M Adams
Mar 5, 2004·Biochimica Et Biophysica Acta·Rizwan S AkhtarKevin A Roth
Jun 1, 2005·Biochemical and Biophysical Research Communications·Ryungsa Kim
Aug 2, 2005·Nature Reviews. Cancer·Lodovico Balducci, William B Ershler
Sep 13, 2005·Mechanisms of Ageing and Development·Christopher K PatilJudith Campisi

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Citations

Mar 5, 2014·Systems and Synthetic Biology·Subhadip Raychaudhuri, Somkanya C Raychaudhuri
Dec 4, 2012·Biochemical and Biophysical Research Communications·Longyun PengXiuren Gao

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