Organ culture for thymus transplantation

Transplantation
R Hong, A L Moore

Abstract

A method is presented for organ culture of postnatal thymus. Such tissue has been used for transplantation for nearly 20 years, but lasting benefit has been observed only in patients with the DiGeorge anomaly. Transplantation in other diseases has produced little or no results. Recently, improved methods for preparing the tissue as well as modifications of the culture media show marked improvement in quality and quantity of tissue suitable for transplant. In addition, using recently available monoclonal antibodies, preservation of vital stromal components can be monitored. The availability of reasonable amounts of high quality thymus tissue for transplantation may stimulate interest in further clinical trials where thymus transplantation may augment or restore T cell immunity.

References

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Citations

Jan 1, 1997·Immunologic Research·B Nikolic, M Sykes
Nov 22, 1997·Current Opinion in Immunology·B Nikolic, M Sykes
Oct 16, 1999·The New England Journal of Medicine·M L MarkertB F Haynes
May 14, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bin LiM Louise Markert
Mar 20, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M Louise MarkertElizabeth A McCarthy
Jun 19, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M L MarkertY J Li
Nov 18, 2004·Journal of Pediatric Surgery·Henry E RiceM Louise Markert
Oct 12, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·C M SteffensA Landay
Jan 6, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R HongL Zhang
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Louise MarkertLaura P Hale
Mar 26, 2020·PloS One·Laura P HaleJoanne Kurtzberg

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22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.