PMID: 696861Oct 1, 1978Paper

Organ culture studies of rat antrum: evidence for an antral inhibitor of gastrin release

The American Journal of Physiology
L M LichtenbergerJ S Trier

Abstract

The regulation of gastrin release in rodent antral mucosal organ cultures was investigated. The tissue was well preserved morphologically and medium gastrin concentration increased steadily throughout a 24-h culture period. The effects of peptone and a bovine serum albumin digest on gastrin release were independently investigated. During the periods these agents were in contact with the tissue, medium gastrin concentration did not differ from those of control cultures. However, treatment cultures released a significantly greater amount of gastrin into the medium than did control cultures during the two posttreatment periods. Prolongation of the period of exposure to peptone did not alter this secretory pattern. The rise in medium gastrin concentration that followed the removal of peptone was directly related to the medium peptone concentration and was partially inhibited by readdition of peptone to cultured antral explants. These results suggest that substances which stimulate gastrin release in vivo may cause the accumulation of an antral inhibitor of gastrin release when exposed to rat antral mucosa in culture.

References

Jul 1, 1977·The Journal of Clinical Investigation·R F HartyJ E McGuigan
Jun 19, 1975·The New England Journal of Medicine·J H Walsh, M I Grossman
Jul 15, 1976·The New England Journal of Medicine·J S Trier
Mar 1, 1975·The Journal of Clinical Investigation·J H WalshJ S Fordtran
Mar 1, 1976·Molecular and Cellular Endocrinology·R LeclercA V Schally
Dec 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·F Stadil, J F Rehfeld
Feb 1, 1972·American Journal of Surgery·B M JacksonJ C Thompson
Aug 1, 1969·The Journal of Clinical Investigation·T H Browning, J S Trier
Nov 1, 1960·Stain Technology·K C RICHARDSONE H FINKE

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