PMID: 8989649Jan 20, 1997Paper

Organ cultures of embryonic rat tongue support tongue and gustatory papilla morphogenesis in vitro without intact sensory ganglia

The Journal of Comparative Neurology
Joseph-Pascal MbieneCharlotte M Mistretta

Abstract

Taste buds on the mammalian tongue are confined to the epithelium of three types of gustatory papillae: the fungiform, circumvallate, and foliate. The gustatory papillae are composed of an epithelium that covers a broad connective tissue core, with extensive innervation to taste bud and nongustatory epithelial locations. Although the temporal sequence of gustatory papilla development is known for several species, factors that regulate initiation, growth, and maintenance of the papillae are not understood. We tested the hypothesis that sensory innervation is required for the initial formation and early morphogenesis of fungiform papillae in a patterned array. An organ culture of the embryonic rat tongue was developed to provide an in vitro system for studying mechanisms involved in fungiform papilla morphogenesis in patterns on the anterior tongue. Tongues were dissected from embryos at 13 days of gestation (E13), a time when the tongue has not yet fully formed and gustatory papillae have not yet appeared, and at 14 days of gestation (E14), when the tongue is well formed and papillae make their initial morphological appearance. Dissected tongues were maintained at the gas/liquid interface in standard organ culture dishes, fed wi...Continue Reading

References

Oct 1, 1991·Developmental Biology·J E KronmillerE J Kollar
Jul 27, 1990·Science·M Kessel, P Gruss
Feb 8, 1991·The Journal of Comparative Neurology·A I Farbman, J P Mbiene
Feb 1, 1972·The Journal of Cell Biology·A I Farbman
May 1, 1982·Experimental Cell Research·D K MacCallumS R Ledbetter
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·M I MorassoT D Sargent
Jun 1, 1994·Current Opinion in Genetics & Development·T Strachan, A P Read
Feb 22, 1994·The Journal of Comparative Neurology·M C Whitehead, D L Kachele
Oct 22, 1993·The Journal of Comparative Neurology·G M Nelson, T E Finger
Jan 1, 1983·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F L Andrés, H Van Der Loos

❮ Previous
Next ❯

Citations

Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ken IwatsukiRobert F Margolskee
May 6, 1998·Journal of Anatomy·L Scott, M E Atkinson
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Liqun MaRobin F Krimm
Apr 14, 2009·Development·Shoba ThirumangalathuLinda A Barlow
Apr 8, 2011·Chemical Senses·Mehmet Hakan OzdenerNancy E Rawson
May 31, 2012·Journal of Visualized Experiments : JoVE·Hakan OzdenerNancy E Rawson
Feb 4, 1999·Annals of the New York Academy of Sciences·L A Barlow, R G Northcutt
Feb 4, 1999·Annals of the New York Academy of Sciences·C M Mistretta
Feb 4, 1999·Annals of the New York Academy of Sciences·B Oakley
Sep 23, 2006·FEBS Letters·Rafael Ortíz-AlvaradoFrancisco Bolaños-Jiménez
Feb 2, 2016·International Journal of Molecular Sciences·Hiroko HishaHiroo Ueno
Dec 22, 2015·Journal of Chemical Neuroanatomy·Ahmed RashwanHiroshi Kiyama
Aug 19, 2009·Annals of the New York Academy of Sciences·Hong-Xiang LiuCharlotte M Mistretta
Aug 19, 2009·Annals of the New York Academy of Sciences·Shoba Thirumangalathu, Linda A Barlow
Aug 30, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hong-Xiang LiuCharlotte M Mistretta
Aug 7, 2013·Developmental Biology·Hong Xiang LiuCharalotte M Mistretta
Oct 26, 2011·Developmental Biology·Hong-Xiang LiuCharlotte M Mistretta
Jan 1, 2014·Developmental Biology·Tao Huang, Robin F Krimm
Sep 25, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Diana Whitaker-MenezesGeorge F Murphy
Sep 10, 1999·Developmental Biology·D J LieblL F Parada
Mar 22, 2003·Developmental Biology·Joshua M H HallThomas E Finger
Dec 8, 2004·Developmental Biology·Hong-Xiang LiuCharlotte M Mistretta
Oct 22, 2016·In Vitro Cellular & Developmental Biology. Animal·Kotaro Honda, Yasuhiro Tomooka
Mar 9, 1999·Neuron·L A Barlow
Oct 12, 2005·Journal of Neurocytology·Irina V NosratChristopher A Nosrat
Oct 12, 2005·Journal of Neurocytology·Bruce Oakley, Martin Witt
Mar 30, 1999·The Journal of Comparative Neurology·J M HallT E Finger
Mar 31, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Ashraf El-SharabySatoshi Wakisaka
Jul 16, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mark A ParkerLinda A Barlow
Jan 24, 2003·The Journal of Comparative Neurology·Joseph-Pascal Mbiene, John David Roberts
Jul 14, 2006·Journal of Neurobiology·Grace F Lopez, Robin F Krimm
Jul 25, 2009·Cell and Tissue Research·Akira Ito, Christopher A Nosrat
Feb 10, 2010·Cell and Tissue Research·Yuko SuzukiKiyoshi Kawakami
Feb 9, 2007·Archives of Histology and Cytology·Charlotte M Mistretta, Hong-Xiang Liu
Jan 8, 2014·Cellular and Molecular Life Sciences : CMLS·Pierfrancesco PagellaThimios A Mitsiadis
Oct 2, 2019·Genesis : the Journal of Genetics and Development·Mohamed IshanHong-Xiang Liu
Oct 2, 2019·ELife·Di FanJean-François Brunet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.