PMID: 3766525Nov 1, 1986Paper

Organ distribution and fate of human platelets: studies of asplenic and splenomegalic patients

American Journal of Hematology
R L Hill-ZobelM F Tsan

Abstract

Little is known about the organ distribution and fate of human platelets. We investigated the kinetics, organ distribution, and fate of autologous 111In-oxine-labeled platelets in 12 normal volunteers, four asplenic subjects, and four patients with splenomegaly. The initial recovery of infused 111In-platelets from the circulation was 97.8 +/- 9.8% (means +/- SD) for asplenic subjects and 26.3 +/- 5.9% for splenomegalic patients as compared to 59.2 +/- 9.3% for normal controls. The mean platelet survival times as derived from the multiple-hit model were 9.2 +/- 1.0 days for asplenics and 6.2 +/- 0.6 days for splenomegalic subjects (8.4 +/- 0.8 days for normals). At 30 min postinfusion, 79.4 +/- 19.2% of the infused 111In-platelets pooled in the spleen of splenomegalic subjects and 42.7 +/- 12.2% in normal controls. There was 7.1 +/- 2.0, 12.6 +/- 3.7, and 29.3 +/- 8.4% pooling in the liver of splenomegalic, normal, and asplenic subjects, respectively. At 10 days postinfusion, 37 and 24% of the 111In-platelets were sequestered in the spleen and liver of normal control subjects, respectively. Similar figures for splenomegalic subjects were 71 and 14%, respectively. In asplenic subjects, 89% was sequestered in the liver. We conclud...Continue Reading

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Sep 23, 1982·The New England Journal of Medicine·R L Hill-ZobelM F Tsan

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Citations

Jul 1, 1994·Stem Cells·J F Bishop
May 31, 2008·British Journal of Haematology·Eldad Hod, Joseph Schwartz
Jan 5, 2001·Baillière's Best Practice & Research. Clinical Gastroenterology·P A McCormick, K M Murphy
Dec 1, 1992·Statistics in Medicine·J P Matthews, K Yuen
Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H NoguchiK Tanikawa
Aug 25, 2020·Journal of Clinical and Translational Hepatology·Sarah Rawi, George Y Wu
Jul 1, 1987·American Journal of Hematology·M F Tsan, R L Hill-Zobel

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