Organ Fabrication Using Pigs as An in Vivo Bioreactor.

The Keio Journal of Medicine
Eiji KobayashiKeiichi Fukuda

Abstract

We present the most recent research results on the creation of pigs that can accept human cells. Pigs in which grafted human cells can flourish are essential for studies of the production of human organs in the pig and for verification of the efficacy of cells and tissues of human origin for use in regenerative therapy. First, against the background of a worldwide shortage of donor organs, the need for future medical technology to produce human organs for transplantation is discussed. We then describe proof-of-concept studies in small animals used to produce human organs. An overview of the history of studies examining the induction of immune tolerance by techniques involving fertilized animal eggs and the injection of human cells into fetuses or neonatal animals is also presented. Finally, current and future prospects for producing pigs that can accept human cells and tissues for experimental purposes are discussed.

References

Aug 9, 1972·Nature: New Biology·R M BinnsJ R Sugar
Jan 18, 1974·Nature·R Y CalneI M Webster
Aug 27, 1981·Nature·N KamadaB Roser
Nov 6, 1998·Science·J A ThomsonJ M Jones
Oct 3, 1953·Nature·R E BILLINGHAMP B MEDAWAR
Jan 7, 1961·Nature·P B MEDAWAR
Dec 24, 2004·The New England Journal of Medicine·Peter J Morris
Jul 8, 2008·Lancet·UNKNOWN Steering Committee of the Istanbul Summit
Jun 19, 2012·Cell Stem Cell·Shunichi SuzukiAkira Onishi
Jan 3, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James E FisherScott L Nyberg
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hitomi MatsunariHiromitsu Nakauchi
May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kiho LeeJin-Hoi Kim
Jun 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jiao HuangLiangxue Lai
Dec 13, 2016·Transplant Immunology·Rieko SakaiShuji Miyagawa
Jan 25, 2017·Nature·Tomoyuki YamaguchiHiromitsu Nakauchi
Jan 28, 2017·Cell·Jun WuJuan Carlos Izpisua Belmonte
Feb 9, 2017·Cell Medicine·Eiji Kobayashi
Oct 11, 2017·Experimental Animals·Eiji KobayashiSatoshi Kunita
Jan 10, 2018·Proceedings of the National Academy of Sciences of the United States of America·Hitomi MatsunariHiroshi Nagashima
Dec 12, 2018·Cell Transplantation·Shugo Tohyama, Eiji Kobayashi

❮ Previous
Next ❯

Citations

Sep 24, 2020·Acta Cirúrgica Brasileira·Eiji Kobayashi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.