Abstract
Organ failure is both a frequent and dangerous condition among adult patients on arrival to an emergency department (ED). The risk of an unfavourable outcome could depend on the underlying aetiology. Knowledge of the relation between aetiology and prognosis could improve the risk stratification at arrival. To describe the relation between organ failure, aetiology and prognosis through 7-day all-cause mortality. An observational three-year cohort study at the ED at Odense University Hospital, Denmark, including all acute adult patients.First-measured vital signs and laboratory values were included to evaluate the presence of the following organ failures: respiratory, coagulation, hepatic, circulatory, cerebral or renal.The primary outcome was 7-day all-cause mortality. Aetiological disease categories were based on primary discharge diagnoses. We described the association between 7-day mortality, aetiology category, site of organ failures and number of patients at risk. Of 40 423 patients with a first-time visit at the ED, 5883(14.6%) had an organ failure on arrival. The median age was 69 (IQR 54-80), and 50% were men. The most frequent aetiology was infection (1495, 25.4%). Seven-day all-cause mortality ranged between aetiologie...Continue Reading
References
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
Jul 1, 1996·Intensive Care Medicine·J L VincentL G Thijs
Apr 15, 2000·Science·L Frank
Sep 29, 2009·Journal of Critical Care·Wendy LimDeborah Cook
Nov 23, 2012·Critical Care : the Official Journal of the Critical Care Forum·Jean-Louis VincentJan Bakker
Oct 2, 2013·Mayo Clinic Proceedings·Lars W AndersenMichael W Donnino
Oct 4, 2013·The Journal of Trauma and Acute Care Surgery·Matthew BennsCarrie A Sims
Feb 6, 2014·Journal of the Chinese Medical Association : JCMA·Jeffrey Che-Hung TsaiHsiu-Ling Chen
Jun 27, 2014·European Journal of Epidemiology·Morten SchmidtHenrik Toft Sørensen
Jul 22, 2014·International Journal of Surgery·Erik von ElmUNKNOWN STROBE Initiative
Jan 9, 2015·BMJ Open·Søren MikkelsenAnne C Brøchner
Mar 11, 2015·Emergency Medicine Journal : EMJ·Mathilde PedersenAnnmarie Touborg Lassen
Jul 15, 2015·American Journal of Respiratory and Critical Care Medicine·Matthew M ChurpekDana P Edelson
Aug 5, 2015·PloS One·Tobias M BingoldUNKNOWN DIVI Intensive Care Registry Group
Nov 12, 2015·Intensive Care Medicine·Sebastian A HaasStefan Kluge
Nov 26, 2015·Clinical Epidemiology·Morten SchmidtHenrik Toft Sørensen
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Christopher W SeymourDerek C Angus
Nov 24, 2016·Chest·Julian M WilliamsJeffrey Lipman
Dec 17, 2016·Shock·Jon Gitz HollerAnnmarie Touborg Lassen
Jan 24, 2018·Surgical Infections·Markus T Ziesmann, John C Marshall
Feb 13, 2018·Critical Care Medicine·Alejandro SchulerVincent X Liu
Apr 25, 2018·Nature Reviews. Nephrology·Christophe Lelubre, Jean-Louis Vincent
Aug 31, 2018·PloS One·Claire MorleyLeigh Kinsman
Nov 2, 2018·PloS One·Peter Bank PedersenAnnmarie Touborg Lassen
Dec 6, 2018·International Emergency Nursing·Anne-Lize AmeszBas de Groot
Aug 1, 2019·Journal of Clinical Medicine·Lisa MellhammarFredrik Kahn
Nov 2, 2019·BMJ Open·Peter Bank PedersenAnnmarie Touborg Lassen
Nov 19, 2020·BMJ Open·Peter Bank PedersenAnnmarie Touborg Lassen