PMID: 3755955Jul 1, 1986Paper

Organ growth and cellular development in ethanol-exposed rats

Alcohol
P V Gallo, J Weinberg

Abstract

Effects of perinatal exposure to ethanol on growth and cellular development were investigated. Alcohol was administered in liquid diets designed to provide optimal nutrition during pregnancy. Pair-fed and ad lib control groups were included. The 3 groups of females were similar in body weight during gestation and lactation, and offspring weights were similar on gestation Day 21 and at birth. By Day 9 of lactation control pups weighted more than both alcohol and pair-fed pups which were similar in body weight. Weights of brain, heart, liver and kidney were reduced in alcohol pups compared to pair-feds and controls. Decreased liver weight reflected both decreased cell size and decreased protein content, but was primarily due to decreased caloric intake. Decreased heart weight appeared to result from a direct effect of ethanol on heart protein content. Even more marked were the adverse effects of ethanol on kidney protein content and kidney DNA (reflecting a decrease in cell number). In contrast, although both absolute brain weight and DNA content were decreased in ethanol-exposed offspring, relative brain weight was increased. Finally, maternal ethanol consumption significantly increased relative placenta weights as well as place...Continue Reading

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Citations

Feb 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·F A MithenR Birchem
Jul 25, 1998·Pharmacology, Biochemistry, and Behavior·J A OsbornJ Weinberg
Sep 3, 2011·Clinical and Experimental Pharmacology & Physiology·Stephen P GrayKaren M Moritz
Feb 1, 1991·Alcoholism, Clinical and Experimental Research·E M Vavrousek-JakubaW J Shoemaker
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·J A OsbornJ Weinberg
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·J A OsbornJ Weinberg
Sep 11, 2010·Journal of the American Society of Nephrology : JASN·Stephen P GrayKaren M Moritz
Apr 25, 2006·Cell Biochemistry and Function·E Arzu Koçkaya, M Turan Akay
Sep 1, 2007·Alcoholism, Clinical and Experimental Research·Maria M GlavasJoanne Weinberg
Jul 26, 2014·The European Journal of Neuroscience·Wendy L ComeauJoanne Weinberg
Jan 26, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Berardino PetrelliGeoffrey G Hicks
Jun 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stephen P GrayKaren M Moritz
Jan 28, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Lisa K AkisonKaren M Moritz
Nov 26, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·J J A De SmidtA Oelofse
Mar 6, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jennifer Slone WilcoxonEva E Redei

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