Organ-on-a-chip engineering: Toward bridging the gap between lab and industry.

Biomicrofluidics
Qasem Ramadan, Mohammed Zourob

Abstract

Organ-on-a-chip (OOC) is a very ambitious emerging technology with a high potential to revolutionize many medical and industrial sectors, particularly in preclinical-to-clinical translation in the pharmaceutical arena. In vivo, the function of the organ(s) is orchestrated by a complex cellular structure and physiochemical factors within the extracellular matrix and secreted by various types of cells. The trend in in vitro modeling is to simplify the complex anatomy of the human organ(s) to the minimal essential cellular structure "micro-anatomy" instead of recapitulating the full cellular milieu that enables studying the absorption, metabolism, as well as the mechanistic investigation of drug compounds in a "systemic manner." However, in order to reflect the human physiology in vitro and hence to be able to bridge the gap between the in vivo and in vitro data, simplification should not compromise the physiological relevance. Engineering principles have long been applied to solve medical challenges, and at this stage of organ-on-a-chip technology development, the work of biomedical engineers, focusing on device engineering, is more important than ever to accelerate the technology transfer from the academic lab bench to specializ...Continue Reading

References

Sep 25, 2001·Analytical Chemistry·Y LiuN Kroutchinina
Feb 6, 2004·Trends in Biotechnology·Ivan MartinMichael Heberer
Jul 15, 2004·The Journal of Bone and Joint Surgery. American Volume·George F MuschlerLinda G Griffith
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ali KhademhosseiniJoseph P Vacanti
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Linda G Griffith, Melody A Swartz
Mar 9, 2006·Alternatives to Laboratory Animals : ATLA·Andrew KnightJonathan Balcombe
Jul 1, 2006·Analytical Chemistry·Bartholomew J KaneMehmet Toner
Jul 13, 2006·Annual Review of Biomedical Engineering·Geert W Schmid-Schönbein
Jun 15, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Taek-Il OhDonghyun Kim
Aug 28, 2007·Cell·Kenneth M Yamada, Edna Cukierman
Aug 30, 2007·Biotechnology Progress·Régis BaudoinEric Leclerc
Sep 1, 2007·Nature Cell Biology·Andreas Wodarz, Inke Näthke
Nov 17, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dongeun HuhShuichi Takayama
Jan 9, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nan XiaDonald E Ingber
Jul 8, 2008·Biomedical Microdevices·Amedeo CarraroCraig Neville
Jan 9, 2009·Biomedical Microdevices·Zeta Tak For YuHsian-Rong Tseng
Jan 13, 2009·Biotechnology and Bioengineering·Daniel A Tatosian, Michael L Shuler
Mar 5, 2009·Journal of Cell Science·Ravi A DesaiChristopher S Chen
Mar 25, 2009·Nature Reviews. Cancer·Don X NguyenJoan Massagué
May 7, 2009·Biotechnology and Bioengineering·Gretchen J MahlerMichael L Shuler
Nov 21, 2009·Biochemical Pharmacology·Eric NovikMartin L Yarmush
Nov 28, 2009·The International Journal of Artificial Organs·Clemens S FritscheJoseph P Vacanti
Jan 8, 2010·Combinatorial Chemistry & High Throughput Screening·James M McKim
Jun 26, 2010·Science·Dongeun HuhDonald E Ingber
Oct 7, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Yue ZhangGordana Vunjak-Novakovic
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 17, 2011·Current Opinion in Cell Biology·Fernando Calvo, Erik Sahai
Jan 19, 2012·Pharmacology & Therapeutics·Anna AstashkinaDavid W Grainger
Mar 27, 2012·Biomaterials·Anna I AstashkinaDavid W Grainger
Apr 28, 2012·Journal of Bioscience and Bioengineering·Yuzo TakayamaKunihiko Mabuchi

❮ Previous
Next ❯

Citations

Jan 8, 2021·Tissue Engineering. Part C, Methods·Mirella EjiugwoGerard O'Connor
Dec 22, 2020·IScience·Barath UdayasuryanScott S Verbridge
Feb 6, 2021·Biochemical Society Transactions·Chrysanthi-Maria Moysidou, Róisín M Owens
Feb 16, 2021·Frontiers in Bioengineering and Biotechnology·Chrysanthi-Maria MoysidouRóisín Meabh Owens
Mar 9, 2021·Critical Reviews in Food Science and Nutrition·Georg SandnerJulian Weghuber
Mar 24, 2021·International Journal of Pharmaceutics·Naveen K ThakralShirlynn Chen
Jun 4, 2021·Tissue Engineering and Regenerative Medicine·Felipe Allan da Silva da CostaJoão Tadeu Ribeiro-Paes
Jun 17, 2021·ACS Biomaterials Science & Engineering·Stefanie FuchsMaria Tenje
Aug 18, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Duygu Bayir GarbiogluMurat Dincer
Aug 28, 2021·International Journal of Molecular Sciences·Teruki Nii, Yoshiki Katayama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.