Organ-On-Chip Technology: The Future of Feto-Maternal Interface Research?

Frontiers in Physiology
Lauren S RichardsonArum Han

Abstract

The placenta and fetal membrane act as a protective barrier throughout pregnancy while maintaining communication and nutrient exchange between the baby and the mother. Disruption of this barrier leads to various pregnancy complications, including preterm birth, which can have lasting negative consequences. Thus, understanding the role of the feto-maternal interface during pregnancy and parturition is vital to advancing basic and clinical research in the field of obstetrics. However, human subject studies are inherently difficult, and appropriate animal models are lacking. Due to these challenges, in vitro cell culture-based studies are most commonly utilized. However, the structure and functions of conventionally used in vitro 2D and 3D models are vastly different from the in vivo environment, making it difficult to fully understand the various factors affecting pregnancy as well as pathways and mechanisms contributing to term and preterm births. This limitation also makes it difficult to develop new therapeutics. The emergence of in vivo-like in vitro models such as organ-on-chip (OOC) platforms can better recapitulate in vivo functions and responses and has the potential to move this field forward significantly. OOC technolog...Continue Reading

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Citations

Oct 29, 2020·Lab on a Chip·Lauren S RichardsonRamkumar Menon
Nov 25, 2020·International Journal of Molecular Sciences·Babak MosavatiE Du
Jan 10, 2021·Annals of Biomedical Engineering·Mackenzie L Wheeler, Michelle L Oyen
Jan 24, 2021·Clinical Therapeutics·Nana MatobaJames W Collins
Mar 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ourlad Alzeus G TantengcoRamkumar Menon
May 20, 2021·Lab on a Chip·Enkhtuya RadnaaRamkumar Menon

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Methods Mentioned

BETA
chips
chip
bioprinting

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