Organ preservation after treatment with induction chemotherapy in patients with locally advanced carcinomas (T3-T4) of oral cavity and oropharynx.

Acta otorrinolaringológica española
Xavier LeónMiquel Quer

Abstract

With the goal of achieving functional preservation, one of the treatment strategies for patients with locally advanced squamous cell carcinomas of the head and neck is to initiate treatment with induction chemotherapy (CT) and decide the second therapeutic manoeuvre depending on the response. The objective of this study is to evaluate organ preservation capacity based on this therapeutic approach in patients with tumours of the oral cavity and oropharynx. A retrospective study of 246 patients with locally advanced carcinomas of the oral cavity or oropharynx (cT3-T4) initially treated with induction CT. After induction CT 28% of patients achieved a complete response of the primary location of the tumour, 43.1% a partial response greater than 50%, and 28.9% a reduction less than 50% or persistence. After the induction CT treatment 70 patients (28.5%) underwent surgical treatment, and 176 (71.5%) radiotherapy (RT) or chemoradiotherapy (CRT). Considering the patients treated non-surgically (n=176), organ preservation for patients with a complete response (n=66) was 65.2%, for those patients with a partial response greater than 50% (n=75) it was 30.7%, and for patients with a partial response less than 50% or persistence (n=35) it w...Continue Reading

References

Jun 13, 1991·The New England Journal of Medicine·UNKNOWN Department of Veterans Affairs Laryngeal Cancer Study GroupWilliam G Henderson
Dec 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan G UrbaDavid E Schuller
May 14, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francis P WordenThomas E Carey
Mar 14, 2009·Head & Neck·Jean-Louis LefebvreUNKNOWN Larynx Preservation Consensus Panel
Mar 26, 2009·Journal of the National Cancer Institute·Yoann PointreauGilles Calais
Nov 7, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lai-ping ZhongZhi-yuan Zhang
Nov 22, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R HittUNKNOWN Spanish Head and Neck Cancer Cooperative Group (TTCC)
Dec 29, 2013·JAMA Otolaryngology-- Head & Neck Surgery·Steven B ChinnDouglas B Chepeha
Jan 10, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P BossiL Licitra
May 18, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Laura GañánXavier León
Mar 30, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Xavier LeónMiquel Quer
Apr 30, 2019·Acta otorrinolaringológica española·Xavier LeónMiquel Quer

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