Organ-specific autoantibodies in patients with rheumatoid arthritis treated with adalimumab: a prospective long-term follow-up

Fabiola AtzeniPiercarlo Sarzi-Puttini


Rheumatoid arthritis (RA) is frequently associated with organ or non-organ-specific autoantibodies or overt autoimmune disorders. Aim of our study was to assess the prevalence and concentration of a panel of organ-specific autoantibodies in patients with RA and to evaluate their relationship with clinical manifestations and treatment efficacy. Clinical and serological data from 20 patients with active RA (3M/17F), aged from 28 to 80 years and 50 healthy controls were analyzed. All patients fulfilled the 1987 American College of Rheumatology (ACR) classification criteria for RA and were treated with adalimumab and methotrexate. At baseline and after 6 months of therapy we tested anti-thyroid antibodies for thyroperoxidase (TPOAb) and thyroglobulin (TgAb) using an automated immunochemiluminescence assay (Immulite 2000, DPC, Los Angeles, CA), and anti-tissue transglutaminase (anti-tTG) using the ELISA assay (Phadia, Freiburg, Germany). Anti-smooth muscle (SMA), anti-liver kidney microsome (LKM), anti-parietal cells (APCA), anti-mitochondrial (AMA) and anti-liver cytosolic protein type 1 (LC1), anti-adrenal gland (ACA), anti-pancreatic islet (ICA) and anti-steroid-producing cell (stCA) antibodies were analyzed using a commercially ...Continue Reading


Jun 1, 1983·Annals of the Rheumatic Diseases·D J ThomasA G Cudworth
Nov 14, 1997·The New England Journal of Medicine·B H TohP A Gleeson
Sep 25, 2001·Current Directions in Autoimmunity·M Pietropaolo, G S Eisenbarth
Mar 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Francesco Cataldo, Vincenzo Marino
May 12, 2004·Lancet·R Hal Scofield
Aug 30, 2005·Annals of the New York Academy of Sciences·Fabiola AtzeniPiercarlo Sarzi-Puttini
Oct 26, 2005·Clinical Rheumatology·Edit BiróGyula Bakó
Oct 21, 2006·Current Opinion in Gastroenterology·Alessio Fasano


Jul 1, 2009·Clinical Reviews in Allergy & Immunology·Nádia Emi AikawaEloísa Bonfá
Jan 18, 2014·Clinical Rheumatology·Jowairiyya Ahmad, Clement E Tagoe
Dec 14, 2011·Current Opinion in Rheumatology·Nikolaos Stathatos, Gilbert H Daniels
Apr 11, 2014·Molecular Medicine Reports·Hyoju YiJi Hyeon Ju
Aug 22, 2017·Frontiers in Endocrinology·Sofie BliddalUlla Feldt-Rasmussen

Related Concepts

Monoclonal Antibodies
Rheumatoid Arthritis
Tissue Specificity
Thyroid Gland
Antirheumatic Drugs, Disease-Modifying

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