May 26, 1999

Organ-specific autoimmune diseases and cytokines

Rinsho byori. The Japanese journal of clinical pathology
Y Hidaka, N Amino


Changes in serum levels of cytokines in organ-specific autoimmune diseases were reviewed. Serum levels of IL-12, critical for the development of Th1 cells, were increased in thyrotoxic patients with Hashimoto's thyroiditis and Graves' disease. Serum levels of IL-5, secreted from Th2 cells, were increased in thyrotoxic patients with Graves' disease, but not in thyrotoxic patients with Hashimoto's thyroiditis. In patients with IDDM, serum levels of Th1 cytokines (IFN-gamma and IL-2) were increased but serum levels of Th2 cytokines (IL-4 and IL-10) were not increased. These findings suggest that measuring the serum concentration of various cytokines is useful to analyze Th1/Th2 balance in autoimmune diseases.

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Mentioned in this Paper

Recombinant Interleukin-10
Recombinant Interleukin-5
Interleukin-10 Binding Activity
Human Interleukin-10 (Nonglycosylated)
Recombinant Interleukin-4
T-helper Cell Type 1
Autoimmune Diseases

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