Organ-specific autoimmunity in granulocyte macrophage-colony stimulating factor (GM-CSF) deficient mice

Autoimmunity
Frank AlderuccioBan-Hock Toh

Abstract

Granulocyte macrophage-colony stimulating factor (GM-CSF) is a pleiotrophic proinflammatory cytokine that augments adaptive immunity by linking it to innate immunity. Experimental autoimmune gastritis is an animal model of human autoimmune gastritis and pernicious anaemia. We have previously shown that GM-CSF is expressed in the gastric mucosa of mice with gastritis initiated by neonatal thymectomy (Gastroenterology 110 (1996) 1791) and that transgenic expression of GM-CSF in the stomach induces autoimmune gastritis in mice (J. Immunol. 166 (2001) 2090). Here we have examined the development of autoimmune gastritis initiated by immunisation or by neonatal thymectomy in GM-CSF deficient mice. We found that gastritis develops in GM-CSF deficient mice initiated by neonatal thymectomy but not by immunisation with gastric antigen. These observations suggest that GM-CSF is not absolutely required for the initiation of autoimmunity and highlights the different conclusions that can be drawn using different disease models.

Citations

Jan 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·John F Seymour
Mar 15, 2005·International Reviews of Immunology·J FieldB-H Toh
Mar 15, 2005·International Reviews of Immunology·Frank AlderuccioBan-Hock Toh
Aug 28, 2004·Clinics in Chest Medicine·Jeffrey J PresneillJohn F Seymour
May 27, 2008·Journal of Autoimmunity·Judith FieldBan-Hock Toh
Oct 3, 2009·Current Opinion in Immunology·Bruce C TrapnellTakuji Suzuki

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