PMID: 8945509Nov 29, 1996Paper

Organ-specific disease provoked by systemic autoimmunity

Cell
V KouskoffD Mathis

Abstract

Rheumatoid arthritis (RA) is a chronic joint disease characterized by leukocyte invasion and synoviocyte activation followed by cartilage and bone destruction. Its etiology and pathogenesis are poorly understood. We describe a spontaneous mouse model of this syndrome, generated fortuitously by crossing a T cell receptor (TCR) transgenic line with the NOD strain. All offspring develop a joint disease highly reminiscent of RA in man. The trigger for the murine disorder is chance recognition of a NOD-derived major histocompatibility complex (MHC) class II molecule by the transgenic TCR; progression to arthritis involves CD4+ T, B, and probably myeloid cells. Thus, a joint-specific disease need not arise from response to a joint-specific antigen but can be precipitated by a breakdown in general mechanisms of self-tolerance resulting in systemic self-reactivity. We suggest that human RA develops by an analogous mechanism.

References

Nov 1, 1978·The Journal of Experimental Medicine·B S AndrewsF J Dixon
Jun 1, 1992·Arthritis and Rheumatism·C NordlingL Klareskog
Dec 1, 1992·Current Opinion in Immunology·P Wordsworth
Jan 1, 1992·Annual Review of Immunology·J F Miller, G Morahan
Sep 6, 1991·Cell·D CosgroveD Mathis
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S CandéiasK Haskins
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Jan 1, 1995·Annual Review of Immunology·L S WickerL B Peterson
Mar 27, 1995·Journal of Immunological Methods·V KouskoffD Mathis
May 3, 1996·Cell·R Tisch, H McDevitt
May 3, 1996·Cell·M FeldmannR N Maini
May 1, 1996·The Journal of Clinical Investigation·D SchmidtC M Weyand
Jan 1, 1996·Annual Review of Immunology·M FeldmannR N Maini
Nov 1, 1996·The Journal of Experimental Medicine·E ScotetE Houssaint

❮ Previous
Next ❯

Citations

Oct 3, 1999·European Journal of Immunology·T OhtekiP S Ohashi
Jan 1, 2000·Arthritis and Rheumatism·S MangialaioD Mathis
Apr 3, 2001·Microscopy Research and Technique·H UnderwoodB Zivkovic
Dec 4, 1998·Springer Seminars in Immunopathology·A P Cope, G Sønderstrup
Dec 4, 1998·Springer Seminars in Immunopathology·R Thomas
Feb 28, 1998·Immunologic Research·Y Chen
Jan 11, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Bernadette Pöllinger
Oct 18, 2006·Springer Seminars in Immunopathology·Peter Boross, J Sjef Verbeek
Jun 21, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Samuel W Hall, Anne Cooke
Nov 1, 2011·Zeitschrift für Rheumatologie·H-D Chang, T Kamradt
Mar 3, 2005·Journal of Clinical Immunology·Toshiyuki Takai
Mar 3, 2005·Journal of Clinical Immunology·Mae-Xhum WongDenise E Jackson
Jul 7, 2011·Journal of Clinical Immunology·Patricia Y TsaoRobert A Eisenberg
Jul 20, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Andreas SchmidBernd J Pichler
Jun 22, 2012·Clinical Reviews in Allergy & Immunology·Rita A MouraJoão E Fonseca
May 5, 2004·Best Practice & Research. Clinical Rheumatology·Paul H Wooley
Feb 28, 2004·Journal of Autoimmunity·Juan J Lafaille
Oct 12, 2004·Joint, Bone, Spine : Revue Du Rhumatisme·Xavier Mariette
Mar 24, 2004·Molecular Immunology·Fei F Shih, Paul M Allen
Jan 15, 2004·Trends in Molecular Medicine·Henrik J Ditzel
Feb 13, 2001·Immunology Letters·M A McGargill, K A Hogquist
Mar 24, 1998·Immunology Today·I B McInnes, F Y Liew
Dec 5, 2000·Current Opinion in Immunology·L Fugger
Apr 1, 1997·Current Biology : CB·D L Mueller, M K Jenkins
Dec 28, 1999·Microbes and Infection·W Chen, S M Wahl
Sep 11, 2002·Cytokine & Growth Factor Reviews·Yoichiro Iwakura
Apr 27, 2001·Trends in Immunology·J J Goronzy, C M Weyand
Apr 7, 2010·Cellular & Molecular Immunology·Di Yu, Carola G Vinuesa
Feb 15, 2007·Nature Clinical Practice. Rheumatology·Rikard Holmdahl
Jan 31, 2006·Nature Immunology·Bryce A BinstadtChristophe Benoist
Feb 14, 2006·Nature Immunology·Kate L JeffreyCharles R Mackay
Jan 10, 2012·Nature Medicine·Hartmut WekerleDavid Serreze

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.