PMID: 9539969Apr 16, 1998Paper

Organ-specific genotoxicity of the potent rodent bladder carcinogens o-anisidine and p-cresidine

Mutation Research
Y F SasakiS Ueno

Abstract

We used a modification of the alkaline single-cell gel electrophoresis (SCG) (Comet) assay to evaluate the in vivo genotoxicity of two potent rodent bladder carcinogens, o-anisidine and p-cresidine, in mouse liver, lung, kidney, brain, and bone marrow, and in the mucosa of stomach, colon, and bladder. Male CD-1 mice (8 weeks old) were sacrificed 3 and 24 h after oral administration of o-anisidine at 690 mg/kg or p-cresidine at 595 mg/kg. Both chemicals were dissolved in olive oil. Both chemicals yielded statistically significant DNA damage in bladder mucosa 3 and 24 h after treatment. o-Anisidine yielded DNA damage in the colon at 3 h, but not at 24 h. No significant effects were observed in any other organs. Our results suggest the importance of the urinary bladder as a sentinel organ for evaluating chemical genotoxicity in rodents.

References

May 1, 1988·Mutagenesis·J Wangenheim, G Bolcsfoldi
Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Feb 1, 1995·Mutation Research·D W FairbairnK L O'Neill
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Citations

Apr 30, 2002·Free Radical Biology & Medicine·Shosuke KawanishiShinji Oikawa
Dec 21, 2006·Toxicologic Pathology·Alan M JeffreyGary M Williams
Nov 1, 2005·International Journal of Toxicology·Carla E TorreyMichael J Santostefano
Dec 14, 2011·Mutation Research·Kunio WadaKyomu Matsumoto
Jul 15, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·M J IatropoulosG M Williams
Mar 10, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Karel NaimanMarie Stiborová
Apr 14, 2005·International Journal of Cancer. Journal International Du Cancer·Marie StiborováEva Frei

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