Organ-Specific Metabolic Shifts of Flavonoids in Scutellaria baicalensis at Different Growth and Development Stages

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jingyuan XuMinjian Qin

Abstract

Scutellaria baicalensis Georgi is a traditional Chinese herbal medicine mainly containing flavonoids that contribute to its bioactivities. In this study, the distributions and dynamic changes of flavonoid levels in various organs of S. baicalensis at different development stages were investigated by UHPLC-QTOF-MS/MS and HPLC-DAD methods. The results indicated that the metabolic profiles of S. baicalensis changed with growth and development. During the initial germination stage, the seeds mainly contained flavonols. With growth, the main kinds of flavonoids in S. baicalensis changed from flavonols to flavanones and flavones. The results also revealed that the accumulation of flavonoids in S. baicalensis is organ-specific. The flavones without 4'-OH groups mainly accumulate in the root and the flavanones mainly accumulate in aerial organs. Dynamic accumulation analysis showed that the main flavonoids in the root of S. baicalensis accumulated rapidly before the full-bloom stage, then changed to a small extent. The results suggested the proper harvest time for the aerial parts was at the initial stage of reproductive growth and the flower buds should be collected before flowering. This study deepening the knowledge of S. baicalensi...Continue Reading

References

Mar 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Z GaoH Xu
Apr 19, 2002·Current Opinion in Plant Biology·Brenda Winkel-Shirley
Jan 1, 1932·Proceedings of the National Academy of Sciences of the United States of America·C P Winsor
Apr 24, 2007·International Journal of Food Microbiology·Bin ShanHarold Corke
Dec 11, 2007·Journal of Experimental Botany·Sofia MocoRic C H De Vos
Jan 13, 2010·Journal of Ethnopharmacology·Xiaofei ShangZhengping Jia
May 1, 2010·Journal of Agricultural and Food Chemistry·Bathilde AugerJean-Marc Routaboul
Mar 26, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Guozhu LiuShouzhuo Yao
Oct 14, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Justyna MierziakAnna Kulma
Feb 9, 2017·Journal of Natural Products·Yu-Ling HuangChien-Chih Chen

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