PMID: 3745957Apr 1, 1986Paper

Organ-specific, phylogenetic, and ontogenetic distribution of the epidermolysis bullosa acquisita antigen

The Journal of Investigative Dermatology
A S PallerR A Briggaman

Abstract

The organ-specific, phylogenetic, and ontogenetic distribution of the epidermolysis bullosa acquisita (EBA) antigen, a newly recognized basement membrane component, was determined using polyclonal sera from patients with EBA and a mouse monoclonal antibody, H3a. Both antibodies are distributed at the basement membrane zone of skin, oral, anal, and vaginal mucosae, and esophagus, but not in kidney, urinary bladder, lymph nodes, placenta, or blood vessels. Both polyclonal and monoclonal EBA antibodies react with a basement membrane antigen in primate and other mammalian skin, but not in avian, amphibian, or reptilian skin. The antigen is present initially in the 8-week-old human fetus, and increases in density until the adult linear pattern is reached at 15 weeks' gestational age.

Citations

Dec 1, 1986·Pediatric Dermatology·A T Lane
Oct 1, 2011·Autoimmunity·Mei ChenDavid T Woodley
Jan 29, 2019·Frontiers in Medicine·Hiroshi KogaKatja Bieber
Jul 1, 1988·The British Journal of Dermatology·C W Lee
Nov 3, 2009·Journal of Cellular and Molecular Medicine·Gheorghe HundorfeanCassian Sitaru
Jan 1, 1989·Archives of Dermatological Research·N OkadaM L Steinberg
Sep 1, 1995·The British Journal of Dermatology·J L MillerD L Ellis
May 16, 2019·The British Journal of Ophthalmology·Antoine RousseauEric Gabison
Jan 1, 1987·Clinics in Dermatology·L A Diaz, G J Anhalt
Aug 1, 1990·Experimental Cell Research·J Kolega, M Manabe

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