Organelle growth control through limiting pools of cytoplasmic components

Current Biology : CB
Nathan W Goehring, Anthony A Hyman

Abstract

The critical importance of controlling the size and number of intracellular organelles has led to a variety of mechanisms for regulating the formation and growth of cellular structures. In this review, we explore a class of mechanisms for organelle growth control that rely primarily on the cytoplasm as a 'limiting pool' of available material. These mechanisms are based on the idea that, as organelles grow, they incorporate subunits from the cytoplasm. If this subunit pool is limited, organelle growth will lead to depletion of subunits from the cytoplasm. Free subunit concentration therefore provides a measure of the number of incorporated subunits and thus the current size of the organelle. Because organelle growth rates are typically a function of subunit concentration, cytoplasmic depletion links organelle size, free subunit concentration, and growth rates, ensuring that as the organelle grows, its rate of growth slows. Thus, a limiting cytoplasmic pool provides a powerful mechanism for size-dependent regulation of growth without recourse to active mechanisms to measure size or modulate growth rates. Variations of this general idea allow not only for size control, but also cell-size-dependent scaling of cellular structures, c...Continue Reading

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A M FallonM Nomura
Dec 1, 1992·The Journal of Cell Biology·K A Johnson, J L Rosenbaum
Dec 1, 1990·The Journal of Cell Biology·J W NewportW G Dunphy
Jun 10, 1988·Science·C Kenyon
Dec 1, 1972·Kybernetik·A Gierer, H Meinhardt
Sep 29, 1972·Science·G G Borisy, J B Olmsted
Dec 1, 1970·The Journal of Cell Biology·B Coyne, J L Rosenbaum
Jan 1, 1982·Annual Review of Biophysics and Bioengineering·T Cavalier-Smith
Dec 19, 2001·The Journal of Cell Biology·E HannakK Oegema
Feb 26, 2003·Cell·Matthew KirkhamAnthony A Hyman
Nov 20, 2003·Nature Cell Biology·Javier E IrazoquiDaniel J Lew
Nov 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Andrea GambaGuido Serini
Feb 21, 2007·Nature Cell Biology·Tommer Ravid, Mark Hochstrasser
Apr 26, 2007·Bulletin of Mathematical Biology·Alexandra JilkineLeah Edelstein-Keshet
Jun 29, 2007·Molecular Biology of the Cell·Paul JorgensenBruce Futcher
Nov 6, 2007·Developmental Cell·Bob Goldstein, Ian G Macara
Nov 14, 2007·The Journal of Cell Biology·Frank R Neumann, Paul Nurse
Jan 24, 2008·Biophysical Journal·Yoichiro MoriLeah Edelstein-Keshet
Feb 26, 2008·Nature Cell Biology·Jadranka LoncarekAlexey Khodjakov
Apr 3, 2008·FEBS Letters·Andrew B Goryachev, Alexandra V Pokhilko
Aug 12, 2008·Seminars in Cell & Developmental Biology·Nedra F WilsonWilliam Meek
Aug 23, 2008·Current Biology : CB·Martin WührTimothy J Mitchison
Nov 18, 2008·Current Biology : CB·Lukasz KozubowskiDaniel J Lew
Nov 17, 2009·Cell·Audrey S HowellDaniel J Lew
Jan 13, 2010·Current Biology : CB·Roger D Sloboda
Feb 9, 2010·Current Biology : CB·Garrett GreenanAnthony A Hyman
May 13, 2010·Molecular Systems Biology·Michael SpringerMarc W Kirschner
Jun 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yoshiyuki AraiMasahiro Ueda
Sep 10, 2010·Cold Spring Harbor Perspectives in Biology·Thomas DechatRobert D Goldman
Oct 12, 2010·Science·Murat AcarAlexander van Oudenaarden
Oct 16, 2010·Cell·Daniel L Levy, Rebecca Heald
Dec 15, 2010·Current Biology : CB·Paul T ConduitJordan W Raff
Jan 29, 2011·Molecular Biology of the Cell·Neeraj SharmaBradley K Yoder
Feb 1, 2011·Nature Methods·Stefanie RedemannHenrik Bringmann

❮ Previous
Next ❯

Citations

May 18, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Dorothy A LeritNasser M Rusan
Aug 27, 2013·Nature Cell Biology·Simone B ReberFrank Jülicher
Dec 26, 2013·The Journal of Cell Biology·Clifford P Brangwynne
Jun 21, 2013·Molecular Biology of the Cell·Yuki HaraAkatsuki Kimura
Sep 8, 2012·Science·Yee-Hung M Chan, Wallace F Marshall
Nov 16, 2013·Science·Matthew C GoodRebecca Heald
Jul 23, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jeffrey B WoodruffAnthony A Hyman
Feb 22, 2013·ELife·Jeremy D Wilbur, Rebecca Heald
Feb 22, 2013·ELife·Daniel Needleman
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Anthony A HymanFrank Jülicher
Aug 22, 2014·Molecular Biology of the Cell·Elisa KannegaardWallace F Marshall
Aug 17, 2014·Experimental Cell Research·Nathan W Goehring
Jul 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·David ZwickerFrank Jülicher
Feb 24, 2015·Current Biology : CB·Stephanie C Weber, Clifford P Brangwynne
Jan 2, 2013·Trends in Cell Biology·Lisa J EdensDaniel L Levy
Nov 18, 2015·Trends in Cell Biology·Kurt M Schmoller, Jan M Skotheim
Oct 7, 2015·Trends in Cell Biology·Wallace F Marshall
Jul 5, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Wallace F Marshall
Feb 8, 2014·Current Biology : CB·Sophie Dumont
Sep 22, 2015·Nature·Kurt M SchmollerJan M Skotheim
Jul 4, 2015·Cell Stress & Chaperones·Shlomi BrielleDaniel Kaganovich
Apr 6, 2016·The ISME Journal·Christopher P KempesTori Hoehler
Jun 4, 2015·The Journal of Cell Biology·Anne-Marie LadouceurPaul S Maddox
Feb 8, 2014·Current Opinion in Cell Biology·Predrag JevtićDaniel L Levy
Mar 11, 2016·Nucleus·Richik N MukherjeeDaniel L Levy
May 7, 2016·Current Biology : CB·Yee-Hung M ChanWallace F Marshall
May 10, 2013·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·John M Robinson
May 9, 2014·Biophysical Journal·Yee-Hung Mark Chan, Wallace F Marshall
Oct 23, 2012·Current Biology : CB·William B LudingtonWallace F Marshall
May 12, 2012·Current Biology : CB·Andrew J Spence, John R Hutchinson
Dec 10, 2013·Current Biology : CB·Kathryne N WrenKarl F Lechtreck
Mar 8, 2014·Current Biology : CB·James B Moseley
Jan 15, 2015·The Journal of Cell Biology·Julie M CraftKarl F Lechtreck
May 3, 2016·The Journal of Physical Chemistry. B·David Harbage, Jané Kondev
Jun 25, 2015·PLoS Computational Biology·Lishibanya MohapatraJane Kondev
May 6, 2016·Annual Review of Biophysics·Lishibanya MohapatraJane Kondev
May 6, 2016·Annual Review of Biophysics·Wallace F Marshall
Jul 22, 2016·Proceedings of the National Academy of Sciences of the United States of America·Doogie OhDaniel J Needleman
Nov 9, 2016·The Journal of Cell Biology·Marc D PanasPaul Anderson
Feb 18, 2016·PloS One·Lucia NovakovaMartin Anger
Feb 9, 2017·Nature Reviews. Molecular Cell Biology·Suzanna L Prosser, Laurence Pelletier
Mar 2, 2017·Traffic·Karl F LechtreckPeiwei Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

© 2021 Meta ULC. All rights reserved