Organelle import of proteins with dual targeting properties into mitochondria and chloroplasts takes place by the general import pathways

Plant Signaling & Behavior
Uwe LangnerR B Klösgen

Abstract

As a consequence of the endosymbiotic gene transfer, most mitochondrial and chloroplastic proteins are nuclear encoded and synthesized in the cytosol as precursor proteins with transit peptides mediating transport to their subcellular destination. It is often assumed that these transit peptides are strictly monospecific for a single organelle. But in recent years more and more proteins have been identified which carry transit peptides that are capable of mediating transport into both mitochondria and chloroplasts. In a recent study we showed with a combination of in silico, in organello, and in vivo approaches that the frequency of such proteins is apparently much higher than usually anticipated.(1) Here we demonstrate with in organello competition experiments that the import of 2 of these dually targeted proteins (GrpE and EF-Tu) takes place by the same import pathways that are used by organelle proteins with "typical" monospecific targeting properties.

References

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May 15, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ralph Bock, Jeremy N Timmis
Feb 14, 2009·Molecular Genetics and Genomics : MGG·Carolina V MorganteMarcio C Silva-Filho
Apr 17, 2009·The New Phytologist·Jan MitschkeStefan A Rensing
Jan 5, 2010·Journal of Plant Physiology·Anja RödigerRalf Bernd Klösgen
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Jun 12, 2012·Biochimica Et Biophysica Acta·Christopher Carrie, Ian Small

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Citations

Aug 10, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Bationa BennewitzRalf Bernd Klösgen

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