Organic calcium channel antagonists provoke acetylcholine receptor autodesensitization on train stimulation of motor nerve

Neuroscience
C C ChangS J Hong

Abstract

The effects of nicardipine and other organic Ca2(+)-channel antagonists on the responses induced by indirect train stimulation (3 s, 50-100 Hz) were studied in mouse phrenic nerve diaphragm preparations. Nicardipine at 1-10 microM, which alone did not affect single or tetanic contractions or the amplitude of evoked endplate potentials and spontaneous miniature endplate potentials, caused tetanic contraction to fade completely in the presence of 0.3 microM neostigmine or 50 microM diisopropylfluorophosphate. In combination with these anticholinesterases, nicardipine caused a severe run-down and shortening of endplate potentials in 1-2 s. This effect on endplate potentials was dependent on stimulus frequency and on extracellular Ca2+. The effect was accelerated by intracellular injection of Ca2+, but retarded by injection of EGTA. The amplitudes of miniature endplate potentials and the evoked endplate depolarization were also depressed during repetitive stimulation. On termination of repetitive stimulation, all postsynaptic responses, including evoked endplate potentials, miniature endplate potentials and single twitches, recovered to pre-train level in 3-10 s. These results suggest that the postsynaptic nicotinic receptors had l...Continue Reading

References

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Citations

Jun 5, 1992·European Journal of Pharmacology·L C Chiou, C C Chang
Oct 15, 1993·European Journal of Pharmacology·M G LópezA G García
Oct 8, 1998·Neuroscience and Behavioral Physiology·R A Giniatullin, L G Magazanik
Nov 5, 1999·Journal of Biomedical Science·C C Chang

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