Organic extracts from African dust storms stimulate oxidative stress and induce inflammatory responses in human lung cells through Nrf2 but not NF-κB

Environmental Toxicology and Pharmacology
Rosa I Rodríguez-CottoBraulio D Jiménez-Vélez

Abstract

The health impact of the global African dust event (ADE) phenomenon in the Caribbean has been vaguely investigated. Heavy metals in ADE and non-ADE extracts were evaluated for the formation of reactive oxygen species (ROS) and antioxidant capacity by cells using, deferoxamine mesylate (DF) and N-acetyl-l-cysteine (NAC). Results show that ADE particulate matter 2.5 (PM2.5) induces ROS and stimulates oxidative stress. Pre-treatment with DF reduces ROS in ADE and Non-ADE extracts and in lung cells demonstrating that heavy metals are of utmost importance. Glutathione-S-transferase and Heme Oxygenase 1 mRNA levels are induced with ADE PM and reduced by DF and NAC. ADE extracts induced Nrf2 activity and IL-8 mRNA levels significantly more than Non-ADE. NF-κB activity was not detected in any sample. Trace elements and organic constituents in ADE PM2.5 enrich the local environment load, inducing ROS formation and activating antioxidant-signaling pathways increasing pro-inflammatory mediator expressions in lung cells.

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Citations

Dec 19, 2015·Mediators of Inflammation·Mario G Ortiz-MartínezBraulio D Jiménez-Vélez
Nov 12, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mengyao ZhaoHing Man Chan
Jan 7, 2017·International Journal of Toxicology·Akiko HondaHirohisa Takano
Oct 14, 2017·The Journal of Physiology·Laura C D Pomatto, Kelvin J A Davies
Jun 12, 2019·Tissue Engineering. Part B, Reviews·Paige Holden, Lakshmi S Nair
Mar 20, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yun GaoLiping Peng

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