Organic nitrate reductase: reassessment of its subcellular localization and tissue distribution and its relationship to the glutathione transferases

The International Journal of Biochemistry
I W TaylorD V Parke

Abstract

1. Using a specific and sensitive GLC method for the determination of glyceryl trinitrate (GTN), its subcellular and tissue distribution were reassessed. Liver was the most active tissue, but activity was also detected in the heart, kidney and gut. In all tissues activity was localized in the soluble fraction. The activity of soluble glutathione S-transferase followed the same pattern, liver exhibiting the highest and the heart the lowest activity. 2. Pretreatment with phenobarbitone and 3-methylcholanthrene stimulated both the glutathione S-transferase and organic nitrate reductase activities. 3. Glutathione S-transferase activity was competitively inhibited by GTN. 4. A comparison of the plasma and hepatic metabolism of GTN revealed higher drug affinity for the hepatic enzyme.

References

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Citations

Apr 27, 2005·British Journal of Pharmacology·L Christofer AddingLars E Gustafsson
Mar 15, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Modesto de CandiaCosimo D Altomare
Jan 21, 2006·The Journal of Pharmacology and Experimental Therapeutics·Mirco GovoniPaola Tocchetti

Related Concepts

Metazoa
Enzyme Activation
Enzyme Induction
Yb-Glutathione-S-Transferase
Trinitrolong
Intestines
Alloenzymes
Kidney
Liver
Methylcholanthrene

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