Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow

Chemical Communications : Chem Comm
Fabio LimaSteven V Ley

Abstract

We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to oxidise boronic acid derivatives by a single electron process. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A straightforward scale up approach using continuous flow photoreactors is also reported affording gram an hour throughput.

References

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Citations

May 28, 2020·Organic & Biomolecular Chemistry·Huiyong YangWanmei Li
Dec 6, 2019·Angewandte Chemie·Joshua P Barham, Burkhard König
Jan 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mara Di FilippoMarcus Baumann
Aug 14, 2020·Chemical Reviews·Stefano Crespi, Maurizio Fagnoni
May 20, 2021·Organic & Biomolecular Chemistry·M Victoria BoboAaron K Vannucci
Aug 5, 2021·ACS Central Science·María González-EsguevillasDavid W C MacMillan
Mar 5, 2019·The Journal of Organic Chemistry·Francisco N FigueroaGabriela Oksdath-Mansilla
Aug 29, 2019·Journal of the American Chemical Society·Daniel KaiserVarinder K Aggarwal
Sep 16, 2021·The Journal of Organic Chemistry·Oliver M GriffithsSteven V Ley
Sep 25, 2021·Chemical Reviews·Lisa CandishSebastian Keess
Sep 10, 2021·Chemistry : a European Journal·Dmitriy M VolochnyukOleksandr O Grygorenko

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Methods Mentioned

BETA
NMR

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