Organic Selenium Reaches the Central Nervous System and Downmodulates Local Inflammation: A Complementary Therapy for Multiple Sclerosis?

Frontiers in Immunology
Juliana Helena Dos Santos de ToledoSofia Fernanda Gonçalves Zorzella-Pezavento

Abstract

Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). The persistent inflammation is being mainly attributed to local oxidative stress and inflammasome activation implicated in the ensuing demyelination and axonal damage. Since new control measures remain necessary, we evaluated the preventive and therapeutic potential of a beta-selenium-lactic acid derivative (LAD-βSe), which is a source of organic selenium under development, to control experimental autoimmune encephalomyelitis (EAE) that is an animal model for MS. Two EAE murine models: C57BL/6 and SJL/J immunized with myelin oligodendrocyte glycoprotein and proteolipid protein, respectively, and a model of neurodegeneration induced by LPS in male C57BL/6 mice were used. The preventive potential of LAD-βSe was initially tested in C57BL/6 mice, the chronic MS model, by three different protocols that were started 14 days before or 1 or 7 days after EAE induction and were extended until the acute disease phase. These three procedures were denominated preventive therapy -14 days, 1 day, and 7 days, respectively. LAD-βSe administration significantly controlled clinical EAE development without triggering overt hepatic and renal dy...Continue Reading

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Citations

Feb 23, 2021·Frontiers in Neuroscience·Nikolay SolovyevBernhard Michalke
May 4, 2021·Frontiers in Neuroscience·Daniel J TorresMarla J Berry

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Methods Mentioned

BETA
flow cytometry
FACS
PCR
atomic absorption spectrometry

Software Mentioned

EAE
SigmaPlot
FlowJo

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