PMID: 9172388Jul 1, 1997Paper

Organic solutes in freezing tolerance

Comparative Biochemistry and Physiology. Part A, Physiology
K B Storey

Abstract

The accumulation of high levels of low-molecular-weight solutes (polyhydric alcohols, saccharides) provides cryoprotection to freeze-tolerant animals by minimizing, via colligative effects, the percentage of body water converted to extracellular ice and the extent of cell volume reduction. Many freeze-tolerant insects accumulate high levels of polyols during autumn cold hardening, whereas freeze-tolerant frogs respond to ice formation in peripheral tissues by synthesizing large amounts of glucose in the liver and rapidly distributing the sugar throughout the body. Seasonal patterns of enzymatic change occur in cold-hardy insects; activities associated with cryoprotectant synthesis rise in the fall, whereas enzymes associated with polyol degradation dominate in the spring. Enzyme profiles also revealed the route of glycerol degradation via polyol dehydrogenase and the novel enzyme, glyceraldehyde kinase. Proton magnetic resonance imaging of freezing and thawing in whole frogs showed a new adaptive effect of the very high glucose levels in core organs; during thawing, organs such as liver and heart melted first, allowing recovery of their vital functions to begin while the rest of the frog thawed. New studies have examined signal...Continue Reading

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Citations

Oct 14, 2006·Die Naturwissenschaften·R MargesinK B Storey
Jul 14, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Kenneth B StoreyThomas A Churchill
Jun 28, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Melody S Clark, M Roger Worland
Jan 27, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Johannes OvergaardMartin Holmstrup
Dec 8, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Annegret NicolaiMaryvonne Charrier
Mar 5, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Kalinka M J Rexer-HuberDavid A Wharton
Sep 14, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Nicholas M TeetsDavid L Denlinger
Jul 1, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·R Gilles
Jul 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Allan Chris M FerreonAshok A Deniz
Jun 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·P A Padilla, M B Roth
Sep 4, 2009·Annual Review of Entomology·Estela L Arrese, Jose L Soulages
Jul 29, 2009·PloS One·Florian Wolschin, Jürgen Gadau
Aug 21, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Caroline M WilliamsBrent J Sinclair
Nov 13, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Steven A Higgins, David L Swanson
Jan 18, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Stine SlotsboMartin Holmstrup
Dec 3, 2011·Journal of Insect Physiology·Nicholas M TeetsDavid L Denlinger
Apr 13, 2012·Physiological and Biochemical Zoology : PBZ·Annegret NicolaiMaryvonne Charrier
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Nov 3, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Brent J Sinclair, David Renault
Mar 10, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hervé ColinetDavid Renault
Dec 1, 2015·Journal of Thermal Biology·Brent J Sinclair
Jun 14, 2003·Biological Reviews of the Cambridge Philosophical Society·Brent J SinclairSteven L Chown
Jun 10, 2011·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Venkateshwar MutyamCarissa M Krane
Dec 20, 2005·Insect Biochemistry and Molecular Biology·Thomas D Pfister, Kenneth B Storey
Aug 1, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Ben KentChristopher J Garvey
Nov 28, 2008·Environmental Entomology·Jack R Layne, Christine F Leszczynski
Apr 25, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Martin HolmstrupMark Bayley

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