Organic solvent-free preparation of keratin nanoparticles as doxorubicin carriers for antitumour activity

Materials Science & Engineering. C, Materials for Biological Applications
Annalisa AluigiGreta Varchi

Abstract

Doxorubicin is one of the most effective chemotherapeutic agents for the treatment of several neoplastic conditions, such as leukemia, neuroblastoma, soft tissue and bone sarcomas, breast cancer, ovarian cancer and others. However, its clinical application is limited by cardiotoxicity, such as cardiomyopathy, that once developed carries a poor prognosis and is frequently fatal. The controlled release of doxorubicin by means of a smart carrier is a strategy to overcome the aforementioned drawback. Herein, doxorubicin/keratin nanoparticles were prepared by loading the drug through ionic gelation and aggregation methods, without using cross linkers, organic solvents neither surfactants. Both methodologies afford nanoparticles with yields up to 100 wt%, depending on the loading amount of doxorubicin. Although aggregation yield smaller nanoparticles (≈100 nm), ionic gelation allows a higher drug loading (up to 30 wt%,). More importantly, nanoparticles obtained through this procedure display a pH-responsive release of the drug: indeed Peppas-Salhin model suggests that, the doxorubicin release mechanism is predominantly controlled by diffusion at pH 7.4 and by protein swelling at pH 5. Moreover, nanoparticles prepared by ionic gelatio...Continue Reading

Citations

Sep 6, 2018·Journal of Biomaterials Science. Polymer Edition·Xuelian ZhiJiantao Lin
Jun 27, 2020·Journal of Biomaterials Science. Polymer Edition·Lijuan WangJiang Yuan
Jul 31, 2020·Journal of Biomaterials Science. Polymer Edition·Xiao HanJian Shen
Nov 23, 2018·International Journal of Molecular Sciences·Elisa MartellaSerena Duchi
Aug 30, 2019·Journal of Photochemistry and Photobiology. B, Biology·Elisa GaioElena Reddi
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Greta AvanciniFrancesca Moret
Nov 23, 2018·International Journal of Biological Macromolecules·Huifang Zhang, Peng Liu

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