PMID: 9431808Feb 12, 1998Paper

Organisation of regulatory elements in two closely spaced Drosophila genes with common expression characteristics

Mechanisms of Development
S GigliottiM Schäfer

Abstract

Sperm tail proteins that are components of a specific structure formed late during spermatid elongation have been found to be encoded by the Mst(3)CGP gene family. These genes have been demonstrated to be regulated both at the transcriptional as well as at the translational level. We report here on the dissection of the regulatory regions for two members of the gene family, Mst84Da and Mst84Db. While high level transcription and negative translational control of Mst84Da is mediated by a short gene segment of 205 nt (-152/+53), Mst84Db expression is controlled by a number of distinct regulatory elements with different effects that all reside within the gene itself. We identify a transcriptional control element between +154 and +216, a translational repression element around +216 to +275 and an RNA stability element within the 3'UTR. Irrespective of the final common expression characteristics, correct regulation for any individual member of the gene family seems to be achieved by very different means. This confirms earlier observations that did not detect any other sequence elements in common apart from the TCE (translational control element).

References

Mar 1, 1991·Molecular and Cellular Biology·A C Lennard, M Fried
May 11, 1988·Nucleic Acids Research·R KuhnM Schäfer
Jan 1, 1985·Cold Spring Harbor Symposia on Quantitative Biology·E M MeyerowitzK VijayRaghavan
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M J GarabedianP C Wensink
Oct 22, 1982·Science·G M Rubin, A C Spradling
Apr 1, 1995·The Journal of Experimental Medicine·K L WrightJ P Ting
Apr 21, 1995·Cell·D CurtisP D Zamore
Jun 6, 1995·Biochemical and Biophysical Research Communications·E SchollenJ J Cassiman
Feb 3, 1995·The Journal of Biological Chemistry·A Gavalas, H Zalkin
Jan 1, 1994·Annual Review of Genetics·P SurdejM Jacobs-Lorena
Oct 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Bownes
Jan 1, 1993·Molecular and Cellular Biology·E MougneauS K Beckendorf
Dec 1, 1995·Molecular and Cellular Biology·M Lossky, P C Wensink
Dec 1, 1995·Developmental Biology·M SchäferU Schäfer
Mar 8, 1996·The Journal of Biological Chemistry·J L MitchamJ E Sims
Apr 25, 1996·Biochemical and Biophysical Research Communications·T Shimokawa, H Fujimoto
Oct 1, 1996·Current Opinion in Genetics & Development·G Seydoux
Jun 1, 1974·Wilhelm Roux' Archiv Für Entwicklungsmechanik Der Organismen·Meredith Gould-Somero, Linda Holland

❮ Previous
Next ❯

Citations

Mar 8, 2013·Developmental Biology·Bridlin BarckmannRenate Renkawitz-Pohl
Aug 5, 2003·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Harriet L Harris, Henk R Braig
Nov 23, 2021·Journal of Molecular Evolution·Rajanikanth Chowdanayaka, Ramachandra Nallur Basappa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.