Organism burden, toxin concentration, and lactoferrin concentration do not distinguish between clinically significant and nonsignificant diarrhea in patients with Clostridium difficile

Diagnostic Microbiology and Infectious Disease
Victoria AnikstNiaz Banaei

Abstract

Clostridium difficile infection is often overdiagnosed in patients with mild diarrhea. We evaluated 4 biomarkers as surrogates for clinically significant diarrhea (≥ 3 episodes in 24 hours) in 59 PCR-positive patients with and 59 PCR-positive patients without clinically significant diarrhea. Organism burden (median tcdB cycle threshold value, 26.9 versus 27.1, P=0.25) and toxin A and B concentrations (toxin A, median, 0 versus 0 ng/mL, P=0.42; toxin B, median, 0 versus 0 ng/mL, P=0.25) were not significantly different between patients with and without clinically significant diarrhea. Fecal lactoferrin concentrations were significantly increased in patients with clinically significant diarrhea (median, 99.0 versus 55.1 μg/mL, P=0.05); however, lactoferrin could not sufficiently classify patients into those with and without clinically significant diarrhea. Interventions that limit C. difficile testing to patients with clinically significant diarrhea are needed to improve the positive predictive value of C. difficile diagnostics.

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Citations

Jan 13, 2017·Journal of Clinical Microbiology·Ferric C FangMark H Wilcox
Sep 29, 2017·Journal of Clinical Microbiology·Lance R PetersonMichael A Lewinski
Apr 14, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Maria SaundersStephen Lewis
Mar 23, 2017·World Journal of Gastroenterology : WJG·Adrián Martínez-MeléndezElvira Garza-González
Apr 10, 2020·Journal of Clinical Microbiology·Johanna SandlundMark H Wilcox
Sep 19, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Chengcheng LiuGenyan Liu
Mar 9, 2021·Expert Review of Molecular Diagnostics·Masako Mizusawa, Karen C Carroll

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