Organism, minimum inhibitory concentration, and outcome in a fungal corneal ulcer clinical trial.

Cornea
Prajna LalithaThomas M Lietman

Abstract

To analyze the minimum inhibitory concentration (MIC) of isolates from fungal keratitis to natamycin and voriconazole and to assess the relationship between organism, MIC, and clinical outcome. Data were collected as part of a randomized, controlled, double-masked clinical trial. Main outcome measures included best spectacle-corrected visual acuity, infiltrate/scar size, time to reepithelialization, and perforation. Speciation and analysis of MIC to natamycin and voriconazole were done according to Clinical and Laboratory Standards Institute standards. The relationship between MIC and organism, organism and outcome measure, and each outcome measure and MIC were assessed. Of the 120 samples obtained in the trial, 84 isolates had an identifiable organism and were available for further analyses. Fusarium spp and Aspergillus spp were the most commonly isolated organisms. MIC was significantly different across the groups of organisms (P = 0.0001). A higher MIC was significantly associated with an increased likelihood of perforation [odds ratio (OR), 2.03; 95% confidence interval (CI), 1.02-4.04; P = 0.04]. There was no significant association between MIC and 3-week visual acuity (OR, 0.058; 95% CI, -0.01 to 0.13; P = 0.11), 3-month ...Continue Reading

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Citations

May 25, 2013·Investigative Ophthalmology & Visual Science·Catherine Q SunThomas M Lietman
Nov 1, 2013·Asia-Pacific Journal of Ophthalmology·Annabel C Y ChewDonald T H Tan
Jan 21, 2014·American Journal of Ophthalmology·Prajna LalithaUNKNOWN Mycotic Ulcer Treatment Trial Group
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