Organismal Fructose Metabolism in Health and Non-Alcoholic Fatty Liver Disease

Biology
Shea SkenderianCholsoon Jang

Abstract

NAFLD has alarmingly increased, yet FDA-approved drugs are still lacking. An excessive intake of fructose, especially in liquid form, is a dietary risk factor of NAFLD. While fructose metabolism has been studied for decades, it is still controversial how fructose intake can cause NAFLD. It has long been believed that fructose metabolism solely happens in the liver and accordingly, numerous studies have investigated liver fructose metabolism using primary hepatocytes or liver cell lines in culture. While cultured cells are useful for studying detailed signaling pathways and metabolism in a cell-autonomous manner, it is equally important to understand fructose metabolism at the whole-body level in live organisms. In this regard, recent in vivo studies using genetically modified mice and stable isotope tracing have tremendously expanded our understanding of the complex interaction between fructose-catabolizing organs and gut microbiota. Here, we discuss how the aberrant distribution of fructose metabolism between organs and gut microbiota can contribute to NAFLD. We also address potential therapeutic interventions of fructose-elicited NAFLD.

References

Nov 1, 1985·The American Journal of Physiology·K R Feingold, A H Moser
Aug 1, 1968·The Journal of Clinical Investigation·F HeinzJ Kirsch
Jan 1, 1972·Acta Medica Scandinavica. Supplementum·E R Froesch
Nov 1, 1993·The American Journal of Clinical Nutrition·P A Mayes
Nov 15, 1996·The Journal of Clinical Investigation·D WassermanE B Rand
Jun 1, 1997·The American Journal of Clinical Nutrition·A AarslandR R Wolfe
Sep 24, 1999·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J P JanssensG Molenberghs
Mar 29, 2000·Advances in Experimental Medicine and Biology·G D'Argenio, G Mazzacca
May 3, 2005·The Journal of Clinical Investigation·Kerry L DonnellyElizabeth J Parks
Aug 27, 2005·Endocrinology·Yeon-Hee HongShinichi Sasaki
Sep 27, 2005·Journal of the American Dietetic Association·Peter L BeyerRichard W McCallum
Nov 10, 2006·The American Journal of Clinical Nutrition·Susanna C LarssonAlicja Wolk
Aug 3, 2007·American Journal of Physiology. Renal Physiology·Michael S GerschTakahiko Nakagawa
Feb 6, 2008·Cell Metabolism·Michael S Brown, Joseph L Goldstein
Apr 9, 2008·Journal of Hepatology·Ina BergheimStephan C Bischoff
Apr 10, 2008·American Journal of Physiology. Endocrinology and Metabolism·Veronique Douard, Ronaldo P Ferraris
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Buck S SamuelJeffrey I Gordon
Apr 15, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Christine P DiggleDavid T Bonthron
Jun 6, 2009·Obesity·Andreas SchwiertzPhilip D Hardt
Jul 25, 2009·European Journal of Nutrition·Laura G Sánchez-LozadaRichard J Johnson
Mar 20, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manal F AbdelmalekUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jul 20, 2011·Bioorganic & Medicinal Chemistry Letters·Xuqing ZhangZhihua Sui
Nov 9, 2011·American Journal of Reproductive Immunology : AJRI·Paria MirmonsefGreg T Spear
Dec 29, 2011·Experimental Diabetes Research·Guenther SilbernagelAndreas Fritsche
Feb 22, 2012·Annals of Internal Medicine·John L SievenpiperDavid J A Jenkins
Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Takuji IshimotoRichard J Johnson
Mar 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Maitreyi RamanKevin P Rioux
Jul 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takuji IshimotoRichard J Johnson
Oct 19, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gijs den BestenDirk-Jan Reijngoud
Jan 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Pamela V ChangRuslan Medzhitov
Mar 29, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karin E KoopmanMireille J Serlie

❮ Previous
Next ❯

Citations

May 11, 2021·World Journal of Clinical Cases·Ioannis IliasLina Zabuliene

❮ Previous
Next ❯

Methods Mentioned

BETA
histone acetylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Diabetes Reports
Robert N HelsleySamir Softic
Current Opinion in Clinical Nutrition and Metabolic Care
Ran Jin, Miriam Vos
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Miriam Vos, Joel E Lavine
© 2021 Meta ULC. All rights reserved