Organization and dynamics of yeast mitochondrial nucleoids

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
I Miyakawa

Abstract

Mitochondrial DNA (mtDNA) is packaged by association with specific proteins in compact DNA-protein complexes named mitochondrial nucleoids (mt-nucleoids). The budding yeast Saccharomyces cerevisiae is able to grow either aerobically or anaerobically. Due to this characteristic, S. cerevisiae has been extensively used as a model organism to study genetics, morphology and biochemistry of mitochondria for a long time. Mitochondria of S. cerevisiae frequently fuse and divide, and perform dynamic morphological changes depending on the culture conditions and the stage of life cycle of the yeast cells. The mt-nucleoids also dynamically change their morphology, accompanying morphological changes of mitochondria. The mt-nucleoids have been isolated morphologically intact and functional analyses of mt-nucleoid proteins have been extensively performed. These studies have revealed that the functions of mt-nucleoid proteins are essential for maintenance of mtDNA. The aims of this review are to summarize the history on the research of yeast mt-nucleoids as well as recent findings on the organization of the mt-nucleoids and mitochondrial dynamics.

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Citations

Mar 10, 2018·The Journal of Cell Biology·Tânia Catarina MedeirosMartin Graef
Nov 7, 2019·Yeast·Bernard Dujon
Aug 23, 2020·Biomolecules·Veronika VozárikováĽubomír Tomáška
Jun 15, 2019·International Journal of Molecular Sciences·Géraldine Farge, Maria Falkenberg
Jan 8, 2021·Mitochondrion·Jan FrankovskyĽubomír Tomáška
May 1, 2021·International Journal of Molecular Sciences·Giulia di PunzioCristina Dallabona
May 1, 2021·International Journal of Molecular Sciences·Chang-Lin ChenChuang-Rung Chang
Feb 11, 2021·Canadian Journal of Microbiology·Alvan Wai, Georg Hausner

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Methods Mentioned

BETA
electron microscopy
electrophoresis
atomic electron microscopy
density gradient centrifugations
fluorescence microscopy
GTPase

Software Mentioned

BLAST
SMART
Phyre

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