PMID: 8587134Dec 1, 1995Paper

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19

Journal of Molecular Evolution
S M HoffmanH W Mohrenweiser

Abstract

Cytochrome P450 genes from the CYP2A, CYP2B, and CYP2F subfamilies form a tight cluster which we have localized on the detailed physical map of human chromosome 19. The corresponding three gene subfamilies are also clustered in the mouse genome, on the region of chromosome 7 known to be syntenic to human chromosome 19. One hundred eight cosmid clones from the human P450 region were assembled into a single contig of 350 kb, restriction mapped, and probed with cDNAs from the three gene subfamilies. A total of 11 genes were identified in humans, including five from the 2A subfamily, three from the 2B subfamily, and three from the 2F subfamily; at least six of the 11 are pseudogenes. The organization of the genes, with members of the three subfamilies intermixed, indicates that the evolution of this gene cluster has been complex. The modern gene arrangement in humans is probably the result of a series of tandem duplications, plus at least one inverted duplication. The identification of all genes and pseudogenes in this cluster also makes it possible to determine the origins of some previously known variant P450 transcripts.

Citations

Jun 3, 1999·Biochemical Pharmacology·S KoskelaH Raunio
Jan 3, 2001·European Journal of Pharmacology·T ArinamiE S Onaivi
Feb 6, 2002·Mutation Research·Ning ChenSusan M G Hoffman
Nov 27, 1999·Molecular Aspects of Medicine·J A Hasler
Oct 31, 2002·Advanced Drug Delivery Reviews·Chun XuRachel F Tyndale
Apr 27, 2000·Toxicology·M BourianW Legrum
Apr 27, 2000·Toxicology·O PelkonenM Pasanen
Oct 27, 2001·British Journal of Clinical Pharmacology·H RaunioO Pelkonen
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·C F HungM A Schuler
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H RaunioY Soini
Jun 6, 2008·Journal of Clinical Pharmacology·J Andrew WilliamsSteven A Wrighton
Jul 17, 2013·Journal of Molecular Biology·Virginie Y Martiny, Maria A Miteva
May 21, 2005·Biochemical and Biophysical Research Communications·Kazunori ShibuyaNobuyoshi Shimizu
Dec 30, 2006·Mutation Research·Susan M G Hoffman, Shengyong Hu
Dec 1, 1995·Nature Genetics·L K AshworthA V Carrano
Jan 16, 2021·Clinical Pharmacology and Therapeutics·Zeruesenay DestaAndrea Gaedigk

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