PMID: 9542529Jul 1, 1997Paper

Organization and expression of human telomere repeat binding factor genes

Somatic Cell and Molecular Genetics
A C YoungA Y Sakaguchi

Abstract

The ends of mammalian chromosomes terminate in structures called telomeres. Recently a human telomere repeat binding factor (TRF1) that binds the vertebrate TTAGGG telomeric repeat in situ was isolated by Chong et al. (1). TRF1 regulates telomere length (2), which is often altered in cancer cells. To understand their genetic organization, TRF1 genes were localized to human chromosomes 13cen, 21cen, and Xq13 by analysis of human monochromosomal hybrids, and by fluorescent in situ hybridization. We also confirmed the recent localization of a human TRF1 gene to chromosome 8, and provide evidence that this locus is alternatively spliced. In contrast to the TRF1 genes on chromosomes 8 and X, the chromosomes 13 and 21 TRF1 genes contained a 60 bp deletion in the coding region. The results suggest that two distinct forms of TRF1 are expressed and that the TRF1 gene family includes at least three pseudogenes whose dispersal in the human genome may have occurred via cDNA intermediates.

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Citations

Oct 10, 2003·Cancer Investigation·Dezhong Joshua LiaoFazlul H Sarkar
Sep 25, 2004·Journal of Cellular Biochemistry·Céline Silva LagesFrançois D Boussin
Sep 28, 2005·Breast Cancer Research and Treatment·Archana ThakurJoshua D Liao
Sep 16, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Indu Pal KaurHarinder Singh
May 29, 2001·The Journal of Biological Chemistry·S KishiK P Lu
Nov 9, 2005·The Journal of Biological Chemistry·Tae Ho LeeXiao Zhen Zhou

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