Organization and nucleotide sequence of the Streptococcus mutans galactose operon

Gene
D AjdićJ J Ferretti

Abstract

The galactose operon encoding a repressor and genes for the Leloir pathway for galactose metabolism (galactokinase, galactose-1-phosphate-uridyl transferase and UDP glucose-4-epimerase) was located adjacent to the multiple sugar metabolism (msm) operon on the chromosome of Streptococcus mutans Ingbritt (serotype c) and the complete nucleotide sequence of this 5-kilobase region was determined. The Leloir pathway was induced by the presence of galactose in the growth medium or following the release of intracellular galactose after uptake and cleavage of alpha-galactosides by the multiple sugar metabolism system. Analysis of the mechanism of galactose transport confirmed the absence of a galactose-specific phosphotransferase system and suggested the presence of an inducible galactose permease. Evidence is presented that galactose transport is independent of the proton motive force and may be ATP-dependent.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Apr 1, 1975·Infection and Immunity·B TerleckyjG D Shockman
Nov 16, 1992·Science·H Nikaido, M H Saier
Oct 1, 1992·Journal of Bacteriology·E K Jagusztyn-KrynickaR Curtiss
Jul 5, 1992·Journal of Molecular Biology·M J Weickert, S Adhya
Aug 1, 1990·Journal of Bacteriology·G F Ames, A K Joshi
Dec 1, 1986·Microbiological Reviews·W J Loesche
May 14, 1969·Journal of Molecular Biology·H W Boyer, D Roulland-Dussoix
Apr 1, 1966·Archives of Oral Biology·B Krasse
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B von Wilcken-Bergmann, B Müller-Hill
Jun 1, 1980·Microbiological Reviews·S Hamada, H D Slade
Mar 1, 1995·Journal of Bacteriology·I C Sutcliffe, R R Russell
Nov 21, 2002·Cellular and Molecular Life Sciences : CMLS·B VrayJ Hoebeke
Apr 1, 1986·Applied and Environmental Microbiology·M W HickeyG R Jago

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Citations

May 15, 2002·FEMS Microbiology Letters·Yi-Ywan M ChenRobert A Burne
Jun 5, 2012·Applied and Environmental Microbiology·Lin ZengRobert A Burne
Oct 7, 2004·Applied and Environmental Microbiology·Jacqueline AbranchesRobert A Burne
Aug 6, 2004·Applied and Environmental Microbiology·Katy VaillancourtChristian Vadeboncoeur
May 15, 2007·Journal of Bacteriology·Dragana Ajdić, Vi T T Pham
Feb 7, 2001·Journal of Bacteriology·E E VaughanW M de Vos
Nov 7, 1999·Oral Microbiology and Immunology·M G CappielloL Daneo-Moore
Dec 11, 2019·Journal of Dental Research·L LeiT Hu
Oct 29, 1998·Journal of Bacteriology·D Ajdić, J J Ferretti
Jun 5, 1998·Microbiology·Yoshihisa YamashitaToshihiko Koga

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