Organization of Areal Connectivity in the Monkey Frontoparietal Network

BioRxiv : the Preprint Server for Biology
Bryan D Conklin


Anatomical connectivity between cortical areas condition the set of observable functional activity in a neural network. The large-scale cortical monkey frontoparietal network (FPN) has been shown to facilitate complex cognitive functions. However, the organization of anatomical connectivity between areas in the FPN supporting such function is unknown. Here, a new connectivity matrix is proposed which shows the FPN utilizes a small-world architecture with an over-reliance on the M9 dynamical relay 3-node motif and degree distributions which can be characterized as single scale. The FPN uses its small-world architecture to achieve the kind of simultaneous integration and specialization of function which cognitive functions like attention and working memory require. Contrary to many real-world networks, the in and out single scale degree distributions illustrate the relatively homogeneous connectivity of each area in the FPN, suggesting an absence of hubs. Crucially, the M9 dynamical relay motif is the optimal arrangement for previously reported near-zero and non-zero phase synchrony to propagate through the network, serving as a candidate topological mechanism. These results signify the impact of the organization of anatomical co...Continue Reading

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