Organization of cellular receptors into a nanoscale junction during HIV-1 adhesion.

PLoS Computational Biology
Terrence M DobrowskyDenis Wirtz

Abstract

The fusion of the human immunodeficiency virus type 1 (HIV-1) with its host cell is the target for new antiretroviral therapies. Viral particles interact with the flexible plasma membrane via viral surface protein gp120 which binds its primary cellular receptor CD4 and subsequently the coreceptor CCR5. However, whether and how these receptors become organized at the adhesive junction between cell and virion are unknown. Here, stochastic modeling predicts that, regarding binding to gp120, cellular receptors CD4 and CCR5 form an organized, ring-like, nanoscale structure beneath the virion, which locally deforms the plasma membrane. This organized adhesive junction between cell and virion, which we name the viral junction, is reminiscent of the well-characterized immunological synapse, albeit at much smaller length scales. The formation of an organized viral junction under multiple physiopathologically relevant conditions may represent a novel intermediate step in productive infection.

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Citations

Oct 9, 2012·The Journal of Biological Chemistry·Robert BlumenthalMathias Viard
Nov 19, 2013·PLoS Computational Biology·Oliwia M SzklarczykHelge Ewers
Jul 16, 2013·Trends in Microbiology·Lesley A EarlSriram Subramaniam
Jun 6, 2013·Virology Journal·Eric BarrowJin Liu
Oct 23, 2013·Scientific Reports·Terrence M DobrowskyDenis Wirtz
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shalini YadavKshatresh Dutta Dubey
Jul 13, 2017·Biophysical Journal·Robert H Pullen, Steven M Abel
Apr 23, 2021·Physical Chemistry Chemical Physics : PCCP·Zhihong ZhangKai Yang
Mar 30, 2012·Biophysical Journal·Jun F AllardP A van der Merwe

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Methods Mentioned

BETA
electron tomography
super resolution microscopy

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