Organization of central synapses by adhesion molecules.

The European Journal of Neuroscience
Alexandra TallafussPhilip Washbourne

Abstract

Synapses are the primary means for transmitting information from one neuron to the next. They are formed during the development of the nervous system, and the formation of appropriate synapses is crucial for the establishment of neuronal circuits that underlie behavior and cognition. Understanding how synapses form and are maintained will allow us to address developmental disorders such as autism, mental retardation and possibly also psychological disorders. A number of biochemical and proteomic studies have revealed a diverse and vast assortment of molecules that are present at the synapse. It is now important to untangle this large array of proteins and determine how it assembles into a functioning unit. Here we focus on recent reports describing how synaptic cell adhesion molecules interact with and organize the presynaptic and postsynaptic specializations of both excitatory and inhibitory central synapses.

References

Oct 13, 1995·The Journal of Biological Chemistry·B A DavletovT C Südhof
May 5, 1995·Cell·K IchtchenkoT C Südhof
Sep 5, 1997·Science·M IrieT C Südhof
Apr 8, 1998·Annual Review of Neuroscience·J G Flanagan, P Vanderhaeghen
Mar 14, 2000·Current Opinion in Cell Biology·K B Hoover, P J Bryant
Jun 17, 2000·Trends in Cell Biology·C C GarnerR L Huganir
Sep 6, 2000·The European Journal of Neuroscience·M OkamotoM Sugita
Sep 9, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B Ranscht
Oct 26, 2000·Trends in Cell Biology·D L BensonG W Huntley
Oct 18, 2001·The Journal of Biological Chemistry·T Biederer, T C Sudhof
Dec 1, 2001·Biological Chemistry·Y GrosskreutzM Kneussel
Jan 29, 2002·Cellular Signalling·Jane L IlsleySteven J Winder
Apr 17, 2002·Cell·Alaa El-Din El-HusseiniDavid S Bredt
Jul 3, 2002·Nature Reviews. Molecular Cell Biology·Klas Kullander, Rüdiger Klein
Jul 19, 2002·Neuron·Hideru TogashiMasatoshi Takeichi
Aug 31, 2002·Science·Thomas BiedererThomas C Südhof
Apr 2, 2003·Nature Genetics·Stéphane JamainUNKNOWN Paris Autism Research International Sibpair Study
May 10, 2003·Nature Cell Biology·Nathalie SansRobert J Wenthold
Jun 11, 2003·Nature Neuroscience·Camin DeanPeter Scheiffele
Jun 27, 2003·Nature·Markus MisslerThomas C Südhof
Oct 2, 2003·Current Opinion in Cell Biology·Masahito YamagataJoshua A Weiner
Nov 1, 2003·Molecular Psychiatry·E BacchelliUNKNOWN International Molecular Genetic Study of Autism Consortium (IMGSAC)
Nov 19, 2003·Neuron·Shernaz X BamjiLouis F Reichardt
Feb 14, 2004·American Journal of Human Genetics·Frédéric LaumonnierSylvain Briault
Jun 25, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kirsten HarveyRobert J Harvey
Sep 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Oliver PrangeAlaa El-Husseini
Sep 24, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip WashbourneA Kimberley McAllister
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip WashbourneAlaa El-Husseini
Nov 16, 2004·European Journal of Cell Biology·Frédérique VaroqueauxNils Brose
Nov 24, 2004·Molecular and Cellular Neurosciences·Junko IidaYutaka Hata
Dec 18, 2004·Neuron·Philip Washbourne
Jan 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yildirim SaraEge T Kavalali

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Citations

Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Karine PozoYukiko Goda
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hyejin LeeEunjoon Kim
May 31, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer L HoyPhilip Washbourne
Feb 19, 2013·Neurochemical Research·Maria Hansen, Peter Schledermann Walmod
Apr 21, 2012·Trends in Neurosciences·Sean I Sheffler-Collins, Matthew B Dalva
Apr 24, 2014·Protein & Cell·Xiaofei YangChen Zhang
Dec 16, 2010·Journal of Neurochemistry·Gavin J Wright, Philip Washbourne
Jul 22, 2010·The European Journal of Neuroscience·Michisuke Yuzaki
Jul 26, 2015·Trends in Neurosciences·Michael A BembenKatherine W Roche
Nov 3, 2017·Physiological Genomics·Y ChenT Casey
Aug 17, 2019·Traffic·Vina Tikiyani, Kavita Babu

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