Organization of chromosome ends in Ustilago maydis. RecQ-like helicase motifs at telomeric regions.

Genetics
Patricia Sánchez-Alonso, Plinio Guzman

Abstract

In this study we have established the structure of chromosome ends in the basidiomycete fungus Ustilago maydis. We isolated and characterized several clones containing telomeric regions and found that as in other organisms, they consist of middle repeated DNA sequences. Two principal types of sequence were found: UTASa was highly conserved in nucleotide sequence and located almost exclusively at the chromosome ends, and UTASb was less conserved in nucleotide sequence than UTASa and found not just at the ends but highly interspersed throughout the genome. Sequence analysis revealed that UTASa encodes an open reading frame containing helicase motifs with the strongest homology to RecQ helicases; these are DNA helicases whose function involves the maintenance of genome stability in Saccharomyces cerevisiae and in humans, and the suppression of illegitimate recombination in Escherichia coli. Both UTASa and UTASb contain a common region of about 300 bp located immediately adjacent to the telomere repeats that are also found interspersed in the genome. The analysis of the chromosome ends of U. maydis provides information on the general structure of chromosome ends in eukaryotes, and the putative RecQ helicase at UTASa may reveal a no...Continue Reading

References

Jan 1, 1992·Annual Review of Biochemistry·E H Blackburn
May 1, 1990·Molecular and Cellular Biology·E DoreC Frontali
Sep 1, 1989·Molecular and Cellular Biology·S Fotheringham, W K Holloman
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J WangS A Leong
Nov 1, 1986·Molecular & General Genetics : MGG·N IrinoH Nakayama
Jan 1, 1988·Chromosoma·T G Kinscherf, S A Leong
May 1, 1988·Molecular and Cellular Biology·V A Zakian, H M Blanton
Sep 20, 1995·Molecular & General Genetics : MGG·M BölkerR Kahmann
Jun 24, 1994·Science·P Borst, G Rudenko
Oct 21, 1994·Science·M S Singer, D E Gottschling
Aug 3, 1995·Nature·M J McEachern, E H Blackburn
Mar 1, 1994·Microbiology·P A Guzmán, J G Sánchez
Jan 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S W MatsonJ W George
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·D de BruinJ V Ravetch
Apr 12, 1996·Science·C E YuG D Schellenberg
Jan 1, 1996·Annual Review of Biochemistry·C W Greider
Jan 1, 1996·Annual Review of Genetics·V A Zakian
Feb 1, 1997·Molecular and Cellular Biology·R Hernandez-RivasA Scherf
Feb 14, 1997·Science·L HarringtonM O Robinson
Feb 20, 1997·Nature·D Shore
Feb 20, 1997·Nature·B van Steensel, T de Lange
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·K HanadaH Ikeda

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Citations

Feb 28, 2002·Fungal Genetics and Biology : FG & B·Alfredo D Martínez-EspinozaScott E Gold
Jun 3, 2005·Molecular Genetics and Genomics : MGG·Peter W InglisM Cléria Valadares-Inglis
Jul 29, 2017·Microbiology Spectrum·Allyson A ErlendsonMichael Freitag
Dec 14, 2004·The Journal of Biological Chemistry·Jeffrey G MandellThomas R Cech
Aug 9, 2019·Fungal Genetics and Biology : FG & B·Barry J Saville, Michael H Perlin
Sep 12, 2006·Nucleic Acids Research·Cathryn RehmeyerMark Farman
Nov 5, 2020·Ecology and Evolution·Julien Y DutheilRegine Kahmann
Dec 17, 2002·Oncogene·Hiroaki Nakayama
Mar 27, 1999·Biochemical and Biophysical Research Communications·S Lin, S Y Ying
Dec 31, 2008·Applied and Environmental Microbiology·Gúmer PérezLucía Ramírez
Feb 3, 2000·Genetics·T LangdonG Jenkins
Oct 1, 2004·The New Phytologist·Regine Kahmann, Jörg Kämper
Feb 28, 2009·Biochimica Et Biophysica Acta·Alejandro ChavezF Brad Johnson
Oct 1, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Hugh M Robertson

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