Organization of cortico-cortical associative projections in rats exposed to ethanol during early postnatal life

Brain Research Bulletin
Alberto GranatoS Giannetti

Abstract

The fine organization of cortico-cortical associative projections was investigated in adult rats exposed to inhalation of ethanol during the first postnatal week. Ethanol-treated and control animals received cortical injections of biotinylated dextran amine combined with N-methyl-D-aspartic acid, in order to obtain a Golgi-like retrograde labeling of associative pyramidal neurons. The results obtained from the analysis of labeling can be summarized as follows: (a) there are fewer associative projection neurons in ethanol-treated than in normal animals; (b) the ratio between the number of supragranular and infragranular associative neurons is higher in ethanol-treated animals compared to controls; (c) the basal dendrites of pyramidal associative cells of layer 2/3 display a simplified dendritic branching in ethanol exposed cases as compared to controls; (d) the cluster analysis shows that normal dendrites can be clearly subdivided into different groups according to their geometric properties, whereas dendrites from animals exposed to ethanol follow less robust grouping criteria. These differences are discussed in consideration of the functional alterations that characterize the fetal alcohol syndrome.

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Citations

Jan 15, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Daniela TavianAlberto Granato
Jun 5, 2003·Brain Research Bulletin·Diego Garbossa, Alessandro Vercelli
Jan 23, 2016·Frontiers in Integrative Neuroscience·Clare J Wilhelm, Marina Guizzetti
Aug 30, 2011·Neurotoxicology and Teratology·R Charles LawrenceSandra J Kelly
May 14, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Stephan Röskam, Michael Koch
Apr 3, 2009·Neurobiology of Learning and Memory·Francesca GelfoMaria Giuseppa Leggio
Aug 27, 2014·Frontiers in Pediatrics·Alberto Granato, Andrea De Giorgio
Nov 27, 2014·Frontiers in Pediatrics·Marina GuizzettiDavid P Gavin
Sep 11, 2012·Journal of Neurodevelopmental Disorders·Andrea De GiorgioAlberto Granato
Jun 19, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emily J RossGregg D Stanwood
Oct 3, 2018·International Journal of Molecular Sciences·Alberto Granato, Benjamin Dering
Feb 8, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Andrea PironeAlberto Granato
May 3, 2019·Brain Structure & Function·John F SmileyMariko Saito
Nov 21, 2019·Alcoholism, Clinical and Experimental Research·Kathleen E ConnerKelly J Huffman
Jul 21, 2021·Biological Psychiatry·Sebastiano Bariselli, David M Lovinger
Jul 4, 2021·Cellular and Molecular Neurobiology·Alberto Granato, Adalberto Merighi

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