PMID: 2126308Nov 16, 1990Paper

Organization of hepatic nitrogen metabolism and its relation to acid-base homeostasis

Klinische Wochenschrift
D Häussinger

Abstract

Hepatic and renal nitrogen metabolism are linked by an interorgan glutamine flux, coupling both renal ammoniagenesis and hepatic ureogenesis to systemic acid base regulation. This is because protein breakdown produces equimolar amounts of NH4+ and HCO3-. A hepatic role in this interorgan team effort is based upon the tissue-specific presence of urea synthesis, which represents a major irreversible pathway for removal of metabolically generated bicarbonate. A sensitive and complex control of bicarbonate disposal via ureogenesis by the extracellular acid-base status creates a feed-back control loop between the acid-base status and the rate of bicarbonate elimination. This bicarbonate-homeostatic mechanism operates without threat of hyperammonemia, because a sophisticated structural and functional organisation of ammonia-metabolizing pathways in the liver acinus uncouples urea synthesis from the vital need to eliminate potentially toxic ammonia.

References

Feb 1, 1990·Klinische Wochenschrift·D HäussingerW Gerok
Jul 1, 1989·Physiological Reviews·K Jungermann, N Katz
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D D Smith, J W Campbell
Jul 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A F MoormanR Charles
Oct 1, 1988·Gastroenterology·P G TraberJ J Gumucio
Oct 1, 1986·Biochemical Pharmacology·D HäussingerW Gerok
Aug 1, 1987·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·W G GuderW Gerok
May 15, 1986·The Biochemical Journal·D HäussingerH Sies
Oct 15, 1985·European Journal of Biochemistry·D Häussinger, W Gerok
Jan 1, 1982·Current Topics in Cellular Regulation·D E Atkinson, M N Camien
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Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S J DodgsonL Mela

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Citations

May 7, 2011·Computational and Mathematical Methods in Medicine·Robert D CohenWen Wang
Jul 1, 1997·Isotopes in Environmental and Health Studies·E J Freyse, S Knospe
Jan 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V ArroyoJ Schölmerich
Sep 14, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·B P Bode, W W Souba
Feb 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yixiang ZhongHye Hyun Yoo

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